Novel Clinical Chemistry Sensing Motif

描述（由申请人提供）：家庭检测技术的发展和应用为糖尿病等慢性疾病的管理带来了革命性的变化。我们在此提出一项计划，开发一种家庭测试试剂盒，用于分析氨和氨基酸，这将彻底改变氨基酸病、尿素循环障碍和其他先天性代谢错误的管理。这些疾病（例如PKU）需要复杂的诊断和临床监测测试。虽然不常见，但患有这些疾病的人需要大量昂贵的医疗护理。治疗需要经常监测血清氨基酸水平，在尿素循环紊乱的情况下，监测氨，以避免显著的发病率和死亡率。事实上，最近美国国立卫生研究院对北京大学的共识声明指出，“建议开发一种可靠的家庭检测方法，以及增加依从性的措施。”为了改善对这些先天性代谢错误患者的护理，我们将开发用于氨和特定氨基酸的光子晶体传感器，患者可用于家庭监测。我们的目标是开发一种传感材料，这种材料可以整合到一种利用手指棒中少量血液的设备中。血液将被放置在光子晶体薄膜传感器上，该传感器将根据特定氨基酸和/或NH4*的浓度迅速改变颜色。分析物感测将通过使用一个简单的Palm pilot型仪器进行监测，该仪器采用彩色CCD相机。结果可以立即显示，并且很容易记录，如果设备操作作为一个病人传记。

DESCRIPTION (provided by applicant): The development and utilization of home testing has revolutionized the management of chronic diseases such as diabetes mellitus. We propose here a plan to develop a home test kit for analytes such as ammonia and amino acids that would revolutionize the management of aminoacidopathies, urea cycle disorders, and other inborn errors of metabolism. These diseases (for example, PKU) require complex testing for diagnosis and clinical monitoring. While uncommon, individuals suffering from these disorders consume significant amounts of expensive medical care. Treatment requires frequent monitoring of serum amino acid levels, and in the case of the urea cycle disorders, ammonia, to avoid significant morbidity and mortality. In fact the recent NIH consensus statement for PKU stated, "Development of a reliable home-testing method is recommended, as well as measures to increase adherence." In order to improve the care of patients with these inborn errors of metabolism, we will develop photonic crystal sensors for ammonia and specific amino acids that patients could use for home monitoring. Our objective is to develop a sensing materials that can be incorporated into a device that utilizes a small amount of blood from a fingerstick. The blood would be placed on a photonic crystal film sensor that would rapidly change color in response to the concentration of a particular amino acid and/or NH4*. The analyte sensing will be monitored by using a simple Palm Pilot-type instrument that utilizes a color CCD camera. The results could be immediately displayed, and easily recorded if the device is operated as a patient biographer.