Novel Clinical Chemistry Sensing Motif

新型临床化学传感基序

基本信息

批准号：
7423945
负责人：
SANFORD A. ASHER
金额：
$ 29.12万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-09-30 至 2010-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7423945
关键词：
Adherence Amino Acids Ammonia Antihypertensive Agents Bilirubin Blood Caring Caucasians Caucasoid Race Chemicals Chronic Disease Clinical Clinical Chemistry Color Complex Consensus Development Devices Diabetes Mellitus Diagnostic Disease Drops Drug Prescriptions Early Intervention Elevation Film Home environment Inborn Errors of Metabolism Inborn Genetic Diseases Individual Laboratories Lipids Live Birth Measures Medical Methods Monitor Morbidity - disease rate Orphan Disease Patient Care Patient Monitoring Patients Personal Digital Assistant Pharmaceutical Preparations Physiological Plasma Population Prevalence Research Personnel Resistance Risk Secondary to Serum Services Technology Testing Tyrosine United States National Institutes of Health base charge coupled device camera clinical Diagnosis cost design glucose monitor hospital utilization improved instrument mortality novel photonics point of care programs response sensor tool urea cycle

项目摘要

DESCRIPTION (provided by applicant): The development and utilization of home testing has revolutionized the management of chronic diseases such as diabetes mellitus. We propose here a plan to develop a home test kit for analytes such as ammonia and amino acids that would revolutionize the management of aminoacidopathies, urea cycle disorders, and other inborn errors of metabolism. These diseases (for example, PKU) require complex testing for diagnosis and clinical monitoring. While uncommon, individuals suffering from these disorders consume significant amounts of expensive medical care. Treatment requires frequent monitoring of serum amino acid levels, and in the case of the urea cycle disorders, ammonia, to avoid significant morbidity and mortality. In fact the recent NIH consensus statement for PKU stated, "Development of a reliable home-testing method is recommended, as well as measures to increase adherence." In order to improve the care of patients with these inborn errors of metabolism, we will develop photonic crystal sensors for ammonia and specific amino acids that patients could use for home monitoring. Our objective is to develop a sensing materials that can be incorporated into a device that utilizes a small amount of blood from a fingerstick. The blood would be placed on a photonic crystal film sensor that would rapidly change color in response to the concentration of a particular amino acid and/or NH4*. The analyte sensing will be monitored by using a simple Palm Pilot-type instrument that utilizes a color CCD camera. The results could be immediately displayed, and easily recorded if the device is operated as a patient biographer.

描述（由申请人提供）：家庭测试的开发和利用已彻底改变了诸如糖尿病之类的慢性疾病的管理。我们在这里提出了一项计划，为氨基酸和氨基酸等分析物开发家庭测试套件，该套件将彻底改变氨基酸疾病，尿素周期疾病和其他代谢错误的管理。这些疾病（例如，PKU）需要进行复杂的诊断和临床监测测试。尽管罕见，但患有这些疾病的人会消耗大量昂贵的医疗服务。治疗需要频繁监测血清氨基酸水平，在尿素周期疾病的情况下，以避免明显的发病率和死亡率。实际上，最近对PKU的NIH共识声明说：“建议开发可靠的家庭测试方法，以及提高依从性的措施。”为了改善这些天生代谢错误的患者的护理，我们将开发用于氨和特定氨基酸的光子晶体传感器，患者可以用于家庭监测。我们的目标是开发一种可以将其掺入使用指尖少量血液的设备中的传感材料。血液将放在光子晶体膜传感器上，该传感器将响应特定氨基酸和/或NH4*的浓度而迅速改变颜色。分析物传感将通过使用使用颜色CCD摄像机的简单棕榈驾驶型仪器来监视。可以立即显示结果，并在设备作为患者传记作者操作时很容易记录。