Novel Clinical Chemistry Sensing Motif

新型临床化学传感基序

• 批准号: 7268913
• 负责人: SANFORD A. ASHER
• 金额: $ 28.85万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7268913
• 关键词: Adherence; Amino Acids; Ammonia; Antihypertensive Agents; Bilirubin; Blood; Caring; Caucasians; Caucasoid Race; Chemicals; Chronic Disease; Clinical; Clinical Chemistry; Color; Complex; Consensus; Development; Devices; Diabetes Mellitus; Diagnostic; Disease; Drops; Drug Prescriptions; Early Intervention; Elevation; Film; Home environment; Inborn Errors of Metabolism; Inborn Genetic Diseases; Individual; Laboratories; Lipids; Live Birth; Measures; Medical; Methods; Monitor; Morbidity - disease rate; Orphan Disease; Patient Care; Patient Monitoring; Patients; Personal Digital Assistant; Pharmaceutical Preparations; Physiological; Plasma; Population; Prevalence; Research Personnel; Resistance; Risk; Secondary to; Serum; Services; Technology; Testing; Tyrosine; United States National Institutes of Health; base; charge coupled device camera; clinical Diagnosis; cost; design; glucose monitor; hospital utilization; improved; instrument; mortality; novel; photonics; point of care; programs; response; sensor; tool; urea cycle

DESCRIPTION (provided by applicant): The development and utilization of home testing has revolutionized the management of chronic diseases such as diabetes mellitus. We propose here a plan to develop a home test kit for analytes such as ammonia and amino acids that would revolutionize the management of aminoacidopathies, urea cycle disorders, and other inborn errors of metabolism. These diseases (for example, PKU) require complex testing for diagnosis and clinical monitoring. While uncommon, individuals suffering from these disorders consume significant amounts of expensive medical care. Treatment requires frequent monitoring of serum amino acid levels, and in the case of the urea cycle disorders, ammonia, to avoid significant morbidity and mortality. In fact the recent NIH consensus statement for PKU stated, "Development of a reliable home-testing method is recommended, as well as measures to increase adherence." In order to improve the care of patients with these inborn errors of metabolism, we will develop photonic crystal sensors for ammonia and specific amino acids that patients could use for home monitoring. Our objective is to develop a sensing materials that can be incorporated into a device that utilizes a small amount of blood from a fingerstick. The blood would be placed on a photonic crystal film sensor that would rapidly change color in response to the concentration of a particular amino acid and/or NH4*. The analyte sensing will be monitored by using a simple Palm Pilot-type instrument that utilizes a color CCD camera. The results could be immediately displayed, and easily recorded if the device is operated as a patient biographer.

描述（由申请人提供）：家庭检测的开发和利用彻底改变了糖尿病等慢性病的管理。我们在此提出一项计划，开发一种用于氨和氨基酸等分析物的家庭测试套件，这将彻底改变氨基酸病、尿素循环障碍和其他先天性代谢缺陷的管理。这些疾病（例如 PKU）需要复杂的测试来进行诊断和临床监测。虽然不常见，但患有这些疾病的人需要花费大量昂贵的医疗费用。治疗需要经常监测血清氨基酸水平，并且在尿素循环障碍的情况下监测氨，以避免显着的发病率和死亡率。事实上，美国国立卫生研究院最近针对北京大学的共识声明指出，“建议开发可靠的家庭检测方法，以及提高依从性的措施。”为了改善对患有这些先天性代谢缺陷的患者的护理，我们将开发用于氨和特定氨基酸的光子晶体传感器，患者可以将其用于家庭监测。我们的目标是开发一种传感材料，可以将其集成到利用指尖采血的少量血液的设备中。血液将被放置在光子晶体薄膜传感器上，该传感器会根据特定氨基酸和/或 NH4* 的浓度快速改变颜色。分析物传感将通过使用彩色 CCD 摄像头的简单掌上型仪器进行监控。如果该设备作为患者传记作者操作，结果可以立即显示并轻松记录。