Workshop on Multi-Scale Muscle Mechanics

描述（由申请人提供）：正常运作的骨骼肌是人类健康的重要组成部分。骨骼肌的宏观行为是由起源于广泛空间尺度的机械特性的整合决定的，从收缩蛋白的结构和行为开始，延伸到多个肌肉和关节在正常和病理改变运动中相互作用的方式。理解这种复杂性需要综合这些层次的发现。但是，虽然个别社会会议可能会考虑这种行为的某些方面，但我们还没有意识到有一个会议考虑了所有方面。因此，我们正在组织2009年多尺度肌肉力学研讨会，以便提供一个论坛，在这个论坛中，肌肉力学功能的许多方面可以详细讨论，首先作为孤立的问题，然后作为整个问题的综合检查的一部分。研讨会的科学目标包括：1)讨论骨骼肌力学在健康和疾病方面的历史发展、当前知识和未来研究；2)讨论正在推进或有潜力推进肌肉功能知识的技术进步；3)强调肌肉力学的综合研究方法；4)讨论如何整合和综合不同尺度的分析结果。这些目标将在研讨会的科学计划中讨论，其中将包括关于肌肉蛋白质、肌肉纤维、整个肌肉、肌肉肌腱单元和多肌肉/多关节系统的机械特性的专题讨论会，这些都是通过实验和计算建模方法发现的。研讨会将提供针对刚开始的研究生的指导报告和针对有经验的肌肉生物力学家的高水平报告。此外，还将邀请全体会议演讲，并根据所提供的摘要进行口头和海报介绍。会议议程的一个独特方面是组成讨论小组，讨论小组将在整个会议过程中详细审查特定问题，然后在会议结束时向整个小组报告。此外，我们的目标是促进有前途的年轻科学家的教育，并加强他们与知名研究人员的互动。因此，我们还将提供以学生为导向的项目，如海报徒步旅行、职业发展小组讨论和指导计划。在这份申请中，我们请求支持降低学员的注册费，并为少数族裔学生和女学生提供旅行津贴计划。我们的最终目标是向科学界和非专业人士传播会议的发现，因此我们将公开会议记录。

DESCRIPTION (provided by applicant): Properly functioning skeletal muscle is a vital component of human health. Skeletal muscles' macroscopic behaviors are determined by the integration of mechanical properties that originate at widely ranging spatial scales, beginning with the structures and behaviors of the contractile proteins and extending through to the manner in which multiple muscles and joints interact during normal and pathologically altered motion. Understanding this complexity requires synthesizing the findings from these many levels. But while individual society meetings may consider particular aspects of this behavior, we are not aware of a single meeting that has considered all of them. Therefore, we are organizing the 2009 Workshop on Multi-scale Muscle Mechanics in order to provide a forum in which many aspects of muscle mechanical function can be discussed in detail, first as isolated questions and then as part of integrative examination of the entire problem. The workshop's scientific objectives include: 1) to discuss the historical development, current knowledge, and future research on skeletal muscle mechanics, in health and disease; 2) to discuss technological advances that are advancing or have the potential to advance knowledge of muscle function; 3) to emphasize an integrative approach in studying muscle mechanics; and 4) to discuss how to integrate and synthesize findings from analyses performed at different scales. These objectives will be addressed in the workshop's scientific program, which will include symposia about the mechanical properties of muscle proteins, muscle fibers, whole muscles, muscle-tendon units, and multi-muscle/multi-joint systems, as uncovered by experimental and computational modeling approaches. The symposia will provide both tutorial presentations targeted to beginning graduate students and high-level presentations for experienced muscle biomechanists. In addition, there will be invited plenary lectures and oral and poster presentations from proffered abstracts. A unique aspect of the meeting agenda is the formation of discussion groups that will examine specific questions in detail over the course of the entire conference, and then report back to the whole group at the end. In addition, we aim to promote the education of promising young scientists and enhance their interactions with established investigators. Therefore, we will also provide student-oriented programming, such as poster walking tours, a career development panel discussion, and a mentoring program. In this application, we request support to reduce the registration fee for trainees and to provide a travel stipend program for students from under-represented minority groups and for female students. Our final objective is to disseminate the meeting's findings to the scientific and lay communities, and so we will make the conference proceedings publically available. PUBLIC HEALTH RELEVANCE: Narrative The proper function of skeletal muscles is essential to good health. In the 2009 Workshop on Multi-Scale Muscle Mechanics, we will provide a forum in which many aspects of muscle mechanical function can be discussed in detail, first as isolated questions and then comprehensively. We will also contribute to the education of future muscle scientists by providing student-oriented programming, a mentoring program, and a travel stipend program.