Workshop on Multi-Scale Muscle Mechanics

多尺度肌肉力学研讨会

• 批准号: 7750396
• 负责人: BRUCE M. DAMON
• 金额: $ 1.5万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-06 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7750396
• 关键词: Address; Back; Behavior; Communities; Computer Simulation; Contractile Proteins; Development; Disease; Education; Educational workshop; Fees; Female; Future; Health; Human; Individual; Joints; Knowledge; Mechanics; Mentors; Minority Groups; Motion; Muscle; Muscle Fibers; Muscle Proteins; Muscle function; Oral; Property; Reporting; Request for Applications; Research; Research Personnel; Scientist; Skeletal Muscle; Societies; Structure; Students; System; Tendon structure; Travel; Underrepresented Minority; Walking; abstracting; career development; experience; graduate student; lectures; meetings; posters; programs; public health relevance; symposium

DESCRIPTION (provided by applicant): Properly functioning skeletal muscle is a vital component of human health. Skeletal muscles' macroscopic behaviors are determined by the integration of mechanical properties that originate at widely ranging spatial scales, beginning with the structures and behaviors of the contractile proteins and extending through to the manner in which multiple muscles and joints interact during normal and pathologically altered motion. Understanding this complexity requires synthesizing the findings from these many levels. But while individual society meetings may consider particular aspects of this behavior, we are not aware of a single meeting that has considered all of them. Therefore, we are organizing the 2009 Workshop on Multi-scale Muscle Mechanics in order to provide a forum in which many aspects of muscle mechanical function can be discussed in detail, first as isolated questions and then as part of integrative examination of the entire problem. The workshop's scientific objectives include: 1) to discuss the historical development, current knowledge, and future research on skeletal muscle mechanics, in health and disease; 2) to discuss technological advances that are advancing or have the potential to advance knowledge of muscle function; 3) to emphasize an integrative approach in studying muscle mechanics; and 4) to discuss how to integrate and synthesize findings from analyses performed at different scales. These objectives will be addressed in the workshop's scientific program, which will include symposia about the mechanical properties of muscle proteins, muscle fibers, whole muscles, muscle-tendon units, and multi-muscle/multi-joint systems, as uncovered by experimental and computational modeling approaches. The symposia will provide both tutorial presentations targeted to beginning graduate students and high-level presentations for experienced muscle biomechanists. In addition, there will be invited plenary lectures and oral and poster presentations from proffered abstracts. A unique aspect of the meeting agenda is the formation of discussion groups that will examine specific questions in detail over the course of the entire conference, and then report back to the whole group at the end. In addition, we aim to promote the education of promising young scientists and enhance their interactions with established investigators. Therefore, we will also provide student-oriented programming, such as poster walking tours, a career development panel discussion, and a mentoring program. In this application, we request support to reduce the registration fee for trainees and to provide a travel stipend program for students from under-represented minority groups and for female students. Our final objective is to disseminate the meeting's findings to the scientific and lay communities, and so we will make the conference proceedings publically available. PUBLIC HEALTH RELEVANCE: Narrative The proper function of skeletal muscles is essential to good health. In the 2009 Workshop on Multi-Scale Muscle Mechanics, we will provide a forum in which many aspects of muscle mechanical function can be discussed in detail, first as isolated questions and then comprehensively. We will also contribute to the education of future muscle scientists by providing student-oriented programming, a mentoring program, and a travel stipend program.

描述(申请人提供)：正常运作的骨骼肌是人类健康的重要组成部分。骨骼肌的宏观行为是由各种力学性质的综合决定的，这些力学性质起源于广泛的空间尺度，从收缩蛋白的结构和行为开始，一直延伸到多个肌肉和关节在正常和病理变化的运动中相互作用的方式。要理解这种复杂性，需要综合这多个层面的研究结果。但是，尽管个别社会会议可能会考虑这种行为的特定方面，但我们还没有意识到有哪一次会议考虑了所有这些方面。因此，我们正在组织2009多尺度肌肉力学研讨会，以便提供一个论坛，在其中可以详细讨论肌肉机械功能的许多方面，首先作为单独的问题，然后作为整个问题的综合审查的一部分。研讨会的科学目标包括：1)讨论骨骼肌力学在健康和疾病中的历史发展、当前知识和未来研究；2)讨论正在推进或有可能促进肌肉功能知识的技术进步；3)强调研究肌肉力学的综合方法；以及4)讨论如何整合和综合不同规模的分析结果。这些目标将在研讨会的科学计划中解决，其中将包括关于肌肉蛋白质、肌肉纤维、整个肌肉、肌肉-肌腱单元和多肌肉/多关节系统的机械特性的研讨会，如实验和计算建模方法所揭示的那样。研讨会将提供针对初学研究生的教程演示和针对有经验的肌肉生物机械师的高级演示。此外，还将举办受邀的全体讲座以及来自所提供摘要的口头和海报演示。会议议程的一个独特方面是组成讨论小组，在整个会议过程中详细审查具体问题，然后在会议结束时向整个小组汇报。此外，我们的目标是促进对有前途的年轻科学家的教育，并加强他们与知名研究人员的互动。因此，我们还将提供面向学生的编程，如海报徒步旅行、职业发展小组讨论和指导计划。在这份申请中，我们请求支持降低学员的注册费，并为代表不足的少数群体的学生和女学生提供旅行津贴计划。我们的最终目标是将会议的发现传播给科学界和非科学界，因此我们将公开会议记录。 公共卫生相关性：叙述骨骼肌的适当功能对健康至关重要。在2009年的多尺度肌肉力学研讨会上，我们将提供一个论坛，在其中可以详细讨论肌肉机械功能的许多方面，首先是作为单独的问题，然后是全面的。我们还将通过提供面向学生的编程、指导计划和旅行津贴计划，为未来肌肉科学家的教育做出贡献。