High Resolution MR Imaging of Damaged Myocardium in Patients with Arrhythmia

心律失常患者受损心肌的高分辨率 MR 成像

• 批准号: 7134723
• 负责人: Benoit Desjardins
• 金额: $ 18.94万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7134723
• 关键词: arrhythmia; clinical research; myocardium; success

DESCRIPTION (provided by applicant): This proposal describes a five-year multidisciplinary career development program, which will enable the Principal Investigator, an MRI and cardiovascular radiologist, to become a productive independent patient-oriented investigator in cardiovascular imaging. Cardiac arrhythmias, frequent in patients with ischemic heart disease, may lead to sudden cardiac arrest, which claims over 450 000 lives per year in the US. They can be prevented by medication, which has a high failure rate and frequent toxicity, or corrected by an Implantable Cardioverter Defibrillator (ICD). 150 000 ICDs were implanted in the US in 2003, number that is growing every year. ICDs have a significant impact on quality of life, as the discharge from an ICD is described as similar to being kicked in the chest by a horse. Radiofrequency ablation under guidance of cardiac electrical mapping, a therapy rapidly growing in importance and popularity, can be used to cure non-life threatening arrhythmias, and minimize or even eliminate the painful discharges experienced by patients with prospective ICDs. The focus of this research is the development and application of novel magnetic resonance imaging (MRI) techniques to improve cardiac ablation therapy. The principal aims are: (1) to develop novel techniques to perform high resolution MRI to assess myocardial damage, (2) to show that MRI can predict the distribution of abnormalities on cardiac electrical mapping due to myocardial damage, making cardiac ablation therapy more efficient, and (3) use MRI to characterize the distribution and progression of cardiac ablation lesions, in order to predict failure of therapy and complications. The career development program has two major components: a technical component, and a translational component. The technical component involves the development of the imaging techniques, to be performed under the mentorship of a leading scientist in biomedical imaging. The translational component involves a didactic component, provided by the University of Michigan's Training Program in Clinical Research, which leads to a Masters degree in Clinical Research Design and Statistical Analysis, and a clinical research component, that involves the testing of the imaging techniques in clinical studies in cardiac electrophysiology, under the mentorship of an internationally recognized pioneer in the field. The program would take place in an environment which has a long tradition of support for junior patient- oriented investigators, and which is at the cutting edge of both medical imaging and cardiac electrophysiology, with extensive clinical, educational and research resources. Relevance: MRI has the potential to make cardiac ablation therapy more efficient and to predict failure and complications of this therapy. This can dramatically improve the lives of people with arrhythmias.

描述（由申请人提供）： 该提案描述了一个为期五年的多学科职业发展计划，这将使主要研究者，MRI和心血管放射科医生，成为一个富有成效的独立的以患者为导向的心血管成像研究者。缺血性心脏病患者常见的心律失常可能导致心脏骤停，在美国每年夺去超过45万人的生命。它们可以通过药物预防，但失败率很高且经常出现毒性，或通过植入式心律转复除颤器（ICD）纠正。2003年，美国植入了15万个ICD，这个数字每年都在增长。ICD对生活质量有重大影响，因为ICD的放电被描述为类似于被马踢中胸部。心脏电标测指导下的射频消融是一种重要性和受欢迎程度迅速增长的治疗方法，可用于治疗非危及生命的心律失常，并最大限度地减少甚至消除植入预期ICD的患者所经历的疼痛放电。本研究的重点是开发和应用新型磁共振成像（MRI）技术来改善心脏消融治疗。主要目标是：（1）开发新的技术来执行高分辨率MRI以评估心肌损伤，（2）表明MRI可以预测由于心肌损伤引起的心脏电标测异常的分布，使心脏消融治疗更有效，以及（3）使用MRI表征心脏消融病变的分布和进展，以预测治疗失败和并发症。职业发展计划有两个主要组成部分：技术部分和翻译部分。技术部分涉及成像技术的发展，将在生物医学成像领域的一位顶尖科学家的指导下进行。翻译部分涉及一个教学部分，由密歇根大学的临床研究培训计划提供，这导致临床研究设计和统计分析硕士学位，以及临床研究部分，涉及心脏电生理临床研究中成像技术的测试，在该领域国际公认的先驱的指导下。该计划将在一个环境中进行，该环境具有支持初级患者为导向的调查人员的悠久传统，并且处于医学成像和心脏电生理学的前沿，具有广泛的临床，教育和研究资源。相关性：MRI有可能使心脏消融治疗更有效，并预测该治疗的失败和并发症。这可以大大改善心律失常患者的生活。