MN Cardiovascular Cell Therapy Clinical Research Network: From AMI to CHF

明尼苏达心血管细胞治疗临床研究网络:从 AMI 到 CHF

基本信息

  • 批准号:
    8215444
  • 负责人:
  • 金额:
    $ 35.42万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-01-01 至 2012-02-29
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The Minnesota Cardiovascular Cell Therapy Clinical Research Network (MnCTN) is ideally suited to promote the evaluation of novel cell therapy strategies for individuals with cardiovascular disease. MnCTN will consist of the consortium of four Minneapolis cutting-edge cardiovascular institutions and the Minnesota Molecular and Cellular Therapeutics (part of the NHLBI-sponsored Production Assistance for Cellular Therapies (PACT) group). The MnCTN is critically important to the mission of the NIH, and the institutions in this application, all of which aim to improve patients' health and save lives, as it provides a unique opportunity to translate basic science of cell therapies into clinical research evaluating the potential of cell therapies as an alternative strategy to halt cardiovascular disease progression and improve patients' outcomes. The institutions of MnCTN have nationally recognized expertise with large clinical patient populations that have unmet treatment need and a high likelihood of benefit from cellular therapy (e.g., acute myocardial infarction, refractory angina, and end-stage heart failure, including patients with left ventricular assist devices). We have an outstanding track record of high enrollment and high quality data in multicenter trials in these areas, including 11 recently completed and/or ongoing cardiovascular cellular therapy clinical trials. Our extensive experience has built expertise in trial design, patient selection, delivery techniques, and endpoint measurements including state-of-the-art imaging and surrogate endpoints. We have the distinct advantage of being one of three PACT institutions, which promotes establishment of standards and application of good manufacturing and clinical practices to the research process. With the infrastructure under this RFA, our expertise will greatly enhance the success of cell therapy protocols at other sites selected to carry out clinical trials. The clinical application of cellular therapies is built on a longstanding success of basic science at the UMN Center for Cardiovascular Repair and the Stem Cell Institute. Such approach, under the structure of this RFA, will generate scientific knowledge and address clinically relevant questions on mechanisms of cell therapies and effects on cardiovascular disease. Using the clinical sites and resources under this RFA, we will establish a bone marrow and peripheral blood stem cell repository, which will be used to identify and characterize the best suitable cells, as well as the future responders to therapy. We believe we are perfectly suited to play an important role in the NHLBI cardiovascular cell therapy research network, capitalizing on our basic research skills, abilities to conduct multi-center clinical trials within an integrative network, and to disseminate knowledge. (End of Abstract)
描述(由申请人提供): 明尼苏达州心血管细胞治疗临床研究网络(MnCTN)非常适合促进心血管疾病患者新型细胞治疗策略的评估。MnCTN将由四个明尼阿波利斯尖端心血管机构和明尼苏达分子和细胞治疗(NHLBI赞助的细胞治疗生产援助(PACT)集团的一部分)组成。MnCTN对于NIH的使命以及该应用中的机构至关重要,所有这些机构都旨在改善患者的健康和挽救生命,因为它提供了一个独特的机会,将细胞疗法的基础科学转化为临床研究,评估细胞疗法作为阻止心血管疾病进展和改善患者预后的替代策略的潜力。MnCTN的机构拥有全国公认的专业知识,拥有未满足治疗需求的大型临床患者人群,并且很有可能从细胞治疗中获益(例如,急性心肌梗死、难治性心绞痛和终末期心力衰竭,包括使用左心室辅助装置的患者)。我们在这些领域的多中心试验中拥有出色的高招募率和高质量数据记录,包括11项最近完成和/或正在进行的心血管细胞治疗临床试验。我们在试验设计、患者选择、输送技术和终点测量(包括最先进的成像和替代终点)方面积累了丰富的经验。我们有三个PACT机构之一,这促进了标准的建立和良好的生产和临床实践的研究过程中的应用的显着优势。凭借RFA的基础设施,我们的专业知识将大大提高细胞治疗方案在其他选定进行临床试验的地点的成功率。细胞疗法的临床应用建立在UMN心血管修复中心和干细胞研究所基础科学的长期成功之上。在RFA的结构下,这种方法将产生科学知识,并解决有关细胞治疗机制和对心血管疾病影响的临床相关问题。利用RFA下的临床站点和资源,我们将建立骨髓和外周血干细胞库,用于识别和表征最合适的细胞以及未来的治疗反应者。我们相信我们非常适合在NHLBI心血管细胞治疗研究网络中发挥重要作用,利用我们的基本研究技能,在综合网络中进行多中心临床试验的能力,以及传播知识。(End摘要)

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Cardiovascular cell therapy and endogenous repair.
  • DOI:
    10.1111/j.1463-1326.2008.00937.x
  • 发表时间:
    2008-11
  • 期刊:
  • 影响因子:
    5.8
  • 作者:
    Taylor, D. A.;Zenovich, A. G.
  • 通讯作者:
    Zenovich, A. G.
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TIMOTHY D HENRY其他文献

TIMOTHY D HENRY的其他文献

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{{ truncateString('TIMOTHY D HENRY', 18)}}的其他基金

MN Regional Cardiovascular Cell Therapy Clinical Res. Network: From AMI to PAD
明尼苏达地区心血管细胞治疗临床研究。
  • 批准号:
    8453392
  • 财政年份:
    2007
  • 资助金额:
    $ 35.42万
  • 项目类别:
MN Regional Cardiovascular Cell Therapy Clinical Res. Network: From AMI to PAD
明尼苏达地区心血管细胞治疗临床研究。
  • 批准号:
    9230423
  • 财政年份:
    2007
  • 资助金额:
    $ 35.42万
  • 项目类别:
MN Regional Cardiovascular Cell Therapy Clinical Res. Network: From AMI to PAD
明尼苏达地区心血管细胞治疗临床研究。
  • 批准号:
    8288424
  • 财政年份:
    2007
  • 资助金额:
    $ 35.42万
  • 项目类别:
MN Regional Cardiovascular Cell Therapy Clinical Res. Network: From AMI to PAD
明尼苏达地区心血管细胞治疗临床研究。
  • 批准号:
    8628864
  • 财政年份:
    2007
  • 资助金额:
    $ 35.42万
  • 项目类别:
MN Cardiovascular Cell Therapy Clinical Research Network: From AMI to CHF
明尼苏达心血管细胞治疗临床研究网络:从 AMI 到 CHF
  • 批准号:
    7337116
  • 财政年份:
    2007
  • 资助金额:
    $ 35.42万
  • 项目类别:
MN Cardiovascular Cell Therapy Clinical Research Network: From AMI to CHF
明尼苏达心血管细胞治疗临床研究网络:从 AMI 到 CHF
  • 批准号:
    7209910
  • 财政年份:
    2007
  • 资助金额:
    $ 35.42万
  • 项目类别:
MN Cardiovascular Cell Therapy Clinical Research Network: From AMI to CHF
明尼苏达心血管细胞治疗临床研究网络:从 AMI 到 CHF
  • 批准号:
    7558564
  • 财政年份:
    2007
  • 资助金额:
    $ 35.42万
  • 项目类别:
MN Cardiovascular Cell Therapy Clinical Research Network: From AMI to CHF
明尼苏达心血管细胞治疗临床研究网络:从 AMI 到 CHF
  • 批准号:
    7747950
  • 财政年份:
    2007
  • 资助金额:
    $ 35.42万
  • 项目类别:
31P NMR MYOCARDIAL BIOENERGETICS IN FAILING MYOCARDIUM
衰竭心肌中的 31P NMR 心肌生物能量学
  • 批准号:
    3051256
  • 财政年份:
    1990
  • 资助金额:
    $ 35.42万
  • 项目类别:
31P NMR MYOCARDIAL BIOENERGETICS IN FAILING MYOCARDIUM
衰竭心肌中的 31P NMR 心肌生物能量学
  • 批准号:
    3051257
  • 财政年份:
    1990
  • 资助金额:
    $ 35.42万
  • 项目类别:

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