Neuromuscular control of the tongue

舌头的神经肌肉控制

• 批准号: 7089877
• 负责人: E. FIONA BAILEY
• 金额: $ 13.74万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7089877
• 关键词: clinical research; human subject; hypoglossal nerve; motor neurons; neuromuscular function; neurophysiology; patient oriented research; polysomnography; pulmonary respiration; sleep; tongue; wakefulness

DESCRIPTION (provided by applicant): This application outlines a plan to conduct research examining the respiratory-related neuromuscular control of the tongue. The plan proposes a series of experiments to be conducted in human subjects that will examine the modulation of human hypoglossal motor unit activities as a function of sleep and wakefulness, in response to respiratory-related sensory stimuli and during volitional movement. These experiments will provide insights into the nervous system (efferent and afferent components) control of the tongue muscles in healthy human subjects that will have implications for the neural control of movement in the broadest sense. The application includes a plan for the acquisition of new theoretical knowledge in cell physiology, systems neurobiology, sleep physiology and practical skills in human neurophysiology, polysomnography and sleep staging. The plan has tremendous potential and will provide the foundation for future studies of lingual motor control in upper airway muscles during more complex oromotor functions such as swallowing. Additional training is needed by the candidate to achieve this potential since the human neurophysiological, polysomnography, sleep state assessment and data analysis techniques are all new to her. The training proposed in this application will extend and develop upon the candidate's previous research experience studying the respiratory-related control of tongue muscle activities in the spontaneously breathing anesthetized rat. The candidate will work with a select group of highly talented co-mentors who will provide expertise in respiratory physiology, sleep and sleep disorders, neurophysiology and motor control. The candidate proposes to conduct all research at the University of Arizona, which offers state of the art facilities for the study of respiratory, sleep and neurophysiology in human subjects and offers advanced courses in cell biology, systems neurobiology, sleep and sleep disorders. Receipt of this award will enable the candidate to go on to develop an independent research program that combines behavioral and neurophysiological approaches to study lingual neuromuscular control in human and lower mammalian model systems.

描述（由申请人提供）：本申请概述了一项计划，以进行研究，检查舌头的发音相关神经肌肉控制。该计划提出了一系列的实验，将在人类受试者中进行，将检查人类舌下神经运动单位活动的调制作为睡眠和觉醒的函数，以响应与睡眠相关的感官刺激和意志运动。这些实验将提供对健康人类受试者舌头肌肉的神经系统（传出和传入组件）控制的见解，这将对最广泛意义上的运动神经控制产生影响。该应用程序包括获取细胞生理学，系统神经生物学，睡眠生理学和人类神经生理学，多导睡眠图和睡眠分期的实践技能的新理论知识的计划。该计划具有巨大的潜力，并将为未来在更复杂的orbital功能（如吞咽）中上气道肌肉的舌运动控制研究提供基础。由于人类神经生理学、多导睡眠图、睡眠状态评估和数据分析技术对候选人来说都是新的，因此候选人需要额外的培训来实现这一潜力。本申请中提出的培训将扩展和发展候选人先前在自主呼吸麻醉大鼠中研究舌肌活动的与麻醉相关的控制的研究经验。候选人将与一组优秀的共同导师合作，他们将提供呼吸生理学，睡眠和睡眠障碍，神经生理学和运动控制方面的专业知识。候选人建议在亚利桑那大学进行所有研究，该大学为人类受试者的呼吸，睡眠和神经生理学研究提供最先进的设施，并提供细胞生物学，系统神经生物学，睡眠和睡眠障碍方面的高级课程。获得该奖项将使候选人能够继续开发一个独立的研究计划，该计划结合了行为和神经生理学方法，以研究人类和低等哺乳动物模型系统中的舌神经肌肉控制。