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Neuromuscular control of the human tongue

人类舌头的神经肌肉控制

基本信息

批准号：
8526446
负责人：
E. FIONA BAILEY
金额：
$ 33.27万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-25 至 2016-08-31
项目状态：
已结题

项目摘要

The tongue is a complex muscular organ that is critical for oro-motor behaviors such as swallowing, breathing, speaking and chewing. The astonishing complexity and precision of the voluntary movements performed by the tongue depend upon the coordination of intrinsic (origin and insertion within the body of the tongue) and extrinsic (attached to bone and inserted into the base of tongue) tongue muscles. Until recently, almost all studies of lingual muscle function whether in speech, respiration or deglutition have concerned themselves with the study of whole muscle electromyographic (EMG) activities. Recently, we characterized respiratory-related tongue muscle and motor unit activities in healthy human subjects as a function of sleep/wake and in slow volitional movements. The results of this work provided de novo insights into lingual motor function and a platform from which to begin studies aimed at identifying how tongue muscles are controlled in more complex volitional behaviors. The current application builds thematically on previous work by the PI and yet departs from previous investigations in incorporating critical elements of the speech production process. Specifically, we propose to examine tongue muscle and motor unit activities and the potential for these activities to be modulated by inputs arising in the respiratory, phonatory (laryngeal) and/or supralaryngeal (oral- articulatory) subsystems. Understanding muscle and MU activities as a function of these influences separately and when successively overlaid is a logical first-step toward understanding how tongue muscle and motor unit activities are modulated in the more complex volitional behavior that is human speech production.

舌头是一个复杂的肌肉器官，对吞咽等口腔运动行为至关重要，呼吸、说话和咀嚼。志愿服务的惊人的复杂性和精确度舌头的运动取决于内在的(起源和插入)的协调舌体内的)和外在的(附着在骨头上并插入舌根的) 舌肌。直到最近，几乎所有关于舌肌功能的研究无论是在言语中，呼吸或吞咽与整个肌肉肌电的研究有关 (EMG)活动。最近，我们描述了与呼吸相关的舌肌和运动单位。健康受试者的活动作为睡眠/清醒和缓慢意志运动的功能。这个这项工作的结果提供了对语言运动功能的新见解，并提供了一个平台开始研究，旨在确定舌肌是如何在更复杂的意志力中控制的行为。当前的应用程序以PI以前的工作为主题构建，但与以前的研究在纳入演讲产生过程的关键要素方面。具体来说，我们建议检查舌肌和运动单位的活动，以及这些活动的潜力由呼吸、发声(喉)和/或喉上(口-喉)的输入调节。发音)子系统。理解肌肉和MU活动作为这些影响的函数分开并在连续重叠时是理解舌头如何肌肉和运动单位的活动受到人类更复杂的意志行为的调节演讲稿。