Neuromuscular control of the tongue

描述（由申请人提供）：本申请概述了一项研究计划，旨在研究舌头与呼吸有关的神经肌肉控制。该计划提出了一系列将在人类受试者中进行的实验，这些实验将检查人类舌下运动单元活动的调节，作为睡眠和清醒的功能，响应呼吸相关的感觉刺激和在意志运动期间。这些实验将提供对健康人类舌头肌肉的神经系统（传出和传入成分）控制的见解，这将对最广泛意义上的运动神经控制产生影响。该应用程序包括获取细胞生理学，系统神经生物学，睡眠生理学和人类神经生理学，多导睡眠图和睡眠分期方面的实践技能的新理论知识的计划。该计划具有巨大的潜力，并将为未来在吞咽等更复杂的运动功能中上呼吸道肌肉的舌运动控制的研究提供基础。候选人需要额外的培训来实现这一潜力，因为人类神经生理学、多导睡眠图、睡眠状态评估和数据分析技术对她来说都是新的。本申请中提出的培训将扩展和发展候选人之前的研究经验，研究自主呼吸麻醉大鼠舌肌活动的呼吸相关控制。候选人将与一组非常有才华的共同导师一起工作，他们将提供呼吸生理学，睡眠和睡眠障碍，神经生理学和运动控制方面的专业知识。候选人建议在亚利桑那大学进行所有研究，亚利桑那大学为人类受试者的呼吸、睡眠和神经生理学研究提供最先进的设施，并提供细胞生物学、系统神经生物学、睡眠和睡眠障碍方面的高级课程。获得该奖项将使候选人能够继续开发一个独立的研究项目，结合行为和神经生理学方法来研究人类和低等哺乳动物模型系统的语言神经肌肉控制。

DESCRIPTION (provided by applicant): This application outlines a plan to conduct research examining the respiratory-related neuromuscular control of the tongue. The plan proposes a series of experiments to be conducted in human subjects that will examine the modulation of human hypoglossal motor unit activities as a function of sleep and wakefulness, in response to respiratory-related sensory stimuli and during volitional movement. These experiments will provide insights into the nervous system (efferent and afferent components) control of the tongue muscles in healthy human subjects that will have implications for the neural control of movement in the broadest sense. The application includes a plan for the acquisition of new theoretical knowledge in cell physiology, systems neurobiology, sleep physiology and practical skills in human neurophysiology, polysomnography and sleep staging. The plan has tremendous potential and will provide the foundation for future studies of lingual motor control in upper airway muscles during more complex oromotor functions such as swallowing. Additional training is needed by the candidate to achieve this potential since the human neurophysiological, polysomnography, sleep state assessment and data analysis techniques are all new to her. The training proposed in this application will extend and develop upon the candidate's previous research experience studying the respiratory-related control of tongue muscle activities in the spontaneously breathing anesthetized rat. The candidate will work with a select group of highly talented co-mentors who will provide expertise in respiratory physiology, sleep and sleep disorders, neurophysiology and motor control. The candidate proposes to conduct all research at the University of Arizona, which offers state of the art facilities for the study of respiratory, sleep and neurophysiology in human subjects and offers advanced courses in cell biology, systems neurobiology, sleep and sleep disorders. Receipt of this award will enable the candidate to go on to develop an independent research program that combines behavioral and neurophysiological approaches to study lingual neuromuscular control in human and lower mammalian model systems.