Prenatal Alcohol Sudden Infant Death Syndrome/Stillbirth

产前酒精婴儿猝死综合症/死产

• 批准号: 7162414
• 负责人: HANNAH C KINNEY
• 金额: $ 62.26万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-26 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7162414
• 关键词: African; Native Americans; alcoholic beverage consumption; autonomic nervous system; biomarker; clinical research; cooperative study; developmental neurobiology; embryo /fetus death; embryo /fetus toxicology; fetal alcohol syndrome; gene environment interaction; genetic polymorphism; health disparity; human genetic material tag; human pregnant subject; infant human (0-1 year); longitudinal human study; molecular pathology; neurogenetics; neuropathology; placenta disorders; postmortem; serotonin; sudden infant death syndrome; teratogens

DESCRIPTION (provided by applicant): This application is in response to a Letter of Invitation (LOI-HD-05-111) to conduct community-linked studies to investigate the role of prenatal alcohol exposure in the risk for SIDS, stillbirth and FAS, and to determine how these different outcomes are inter-related. The proposed research will be conducted by the investigators the Prenatal Alcohol, SIDS, and Stillbirth (PASS) Research Network in a cooperative agreement with NICHD and NIAAA. This research involves the collaboration of: 1) two comprehensive clinical sites serving populations that are high risk for prenatal alcohol exposure, SIDS, and stillbirth, i.e. the American Indians in the Northern Plains and the Cape Coloured in Cape Town, South Africa; 2) a central Developmental Biology and Pathology Center (DBPC); 3) a central Data Coordinating and Analysis Center (DCAC); 4) a central Physiology Assessment Center (PAC); and 5) program scientists and officers at the NICHD and NIAAA. This particular application pertains to the Developmental Biology and Pathology Center (DBPC) of the PASS Network. The experimental design involves a prospective study of 12,000 pregnancies, and two retrospective, autopsy-based studies of SIDS and stillbirth. The long-term goals of the SAFE PASSAGE STUDY are to decrease fetal and infant mortality and improve child health in communities at high risk for prenatal maternal alcohol consumption. The Specific Aims of the Network are as follows: 1) to determine the association between prenatal alcohol exposure and the risk for SIDS and stillbirth; 2) to determine the role of the timing, pattern, and amount of prenatal alcohol exposure and other environmental factors in the risk for morbidity and mortality in early human life; 3) to determine the role of specific genes in modifying the risk for morbidity and mortality in early life that is associated with prenatal alcohol exposure; 4) to determine the role of alcohol exposure during pregnancy, and interactions among alcohol exposure and environmental and genetic modifiers, in altering profiles of autonomic activity of the fetus and infant, and neurobehavioral outcomes in the infant; 5) to determine the role of maternal alcohol exposure, as influenced by specific environmental and genetic factors, in the impairment of placental function, and thereby the increased risk for fetal and/or infant morbidity and mortality; and 6. To determine abnormalities in key neurotransmitter systems in the brains of fetuses and/or infants that convey risk for sudden death, and to determine the role of prenatal alcohol exposure, as influenced by specific environmental and genetic factors, in their pathogenesis. The mission of the DBPC is to ensure the proper classification of fetal and infant deaths at autopsy, perform basic research related to alcohol induced injury in the human brain and placenta, and oversee genetic analysis in the targeted populations.

描述（由申请人提供）：此申请是响应邀请信（LOI-HD-05-111）进行社区关联研究，以调查产前酒精暴露在SIDS，Stilts，Stiltbirth和FAS风险中的作用，并确定如何确定这些不同的结果是相互关联的。拟议的研究将由研究人员与NICHD和NIAAA的合作协议中进行产前酒精，SIDS和Stilt -Pass（Pass）研究网络进行。这项研究涉及以下合作：1）两个全面的临床场所，为人群提供高风险的人口，小岛屿发展中国家和死产，即北部平原的美洲印第安人，以及南非开普敦的开普山。 2）中央发育生物学和病理中心（DBPC）； 3）中央数据协调和分析中心（DCAC）； 4）中央生理评估中心（PAC）； 5）NICHD和NIAAA的计划科学家和官员。该特定应用与通行网络的发展生物学和病理中心（DBPC）有关。实验设计涉及对12,000例怀孕的前瞻性研究，以及两项回顾性的，基于尸检的SID和死产研究。安全通道研究的长期目标是降低胎儿和婴儿死亡率，并改善产前孕妇饮酒风险高风险的社区的儿童健康。 网络的具体目的如下：1）确定产前酒精暴露与SID和死产风险之间的关联； 2）确定产前酒精暴露和其他环境因素在人类早期生命中发病和死亡的风险中的作用； 3）确定特定基因在改变与产前酒精相关的早期发病率和死亡率的风险中的作用； 4）确定妊娠期间酒精暴露的作用，以及酒精暴露以及环境和遗传修饰符之间的相互作用，在改变胎儿和婴儿的自主活动的特征以及婴儿的神经行为结局中； 5）确定受特定环境和遗传因素的影响在胎盘功能受损中的孕产妇暴露的作用，从而增加胎儿和/或婴儿发病率和死亡的风险； 6。确定胎儿和/或婴儿的关键神经递质系统的异常，这些系统传达了猝死风险，并确定受特定环境和遗传因素在发病机构中的影响，并确定产前酒精暴露的作用。 DBPC的任务是确保在尸检时正确分类胎儿和婴儿死亡，进行与酒精诱导的人脑和胎盘损伤有关的基础研究，并监督目标种群中的遗传分析。