Female reproductive health preservation by Nicotinamide Adenine Dinucleotide (NAD+) and Sirtuin2 (SIRT2)

通过烟酰胺腺嘌呤二核苷酸（NAD）和Sirtuin2（SIRT2）来保护女性生殖健康

• 批准号: nhmrc : 1103689
• 负责人: Dr Lindsay Wu
• 金额: $ 28.17万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/female-reproductive-health-sirtuin2-sirt2/662687
• 关键词: Female; reproductive; health; preservation; Nicotinamide

Cancer treatment can be severely toxic to women’s eggs. Increasing numbers of women who survive cancer therefore become infertile and prematurely deprived of hormonal support whilst still in their reproductive years. This project will use state-of-the-art techniques to interrogate newly uncovered pathways that can protect eggs from treatment-induced injury thereby greatly improving the quality of life for female cancer survivors.

癌症治疗可能会对女性卵子产生严重毒性。因此，越来越多的在癌症中幸存下来的女性变得不育，并在仍处于生育年龄时过早地剥夺了激素支持。该项目将使用最先进的技术来询问新发现的保护卵子免受治疗损伤的途径，从而极大地提高女性癌症幸存者的生活质量。