Nicotinamide adenine dinucleotide (NAD+)-raising agents for improving oocyte quality

用于改善卵母细胞质量的烟酰胺腺嘌呤二核苷酸 (NAD) 提高剂

• 批准号: nhmrc : GNT1122484
• 负责人: Dr Lindsay Wu
• 金额: $ 44.58万
• 依托单位国家: 澳大利亚
• 项目类别: Development Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/nicotinamide-adenine-dinucleotide-oocyte-quality/1347280
• 关键词: Nicotinamide; adenine; dinucleotide; NAD+; raising

Many women cannot have children because of suboptimal egg quality, often due to aging. Currently, the only option is to use better quality eggs donated from another woman. This project will use pharmacological agents to promote recently discovered pathways in eggs central to determining quality. Importantly, we will investigate a simple and practical approach that can be used in clinics for augmenting these pathways to improve oocyte quality for the first time.

许多女性不能生育是因为卵子质量不佳，通常是由于衰老。目前，唯一的选择是使用另一名妇女捐赠的质量更好的卵子。该项目将使用药理学试剂来促进最近发现的鸡蛋中决定质量的关键途径。重要的是，我们将研究一种简单实用的方法，可用于临床，以增加这些途径，以提高卵母细胞的质量首次。