Nicotinamide adenine dinucleotide (NAD+)-raising agents for improving oocyte quality

用于改善卵母细胞质量的烟酰胺腺嘌呤二核苷酸 (NAD) 提高剂

• 批准号: nhmrc : 1122484
• 负责人: Dr Lindsay Wu
• 金额: $ 30.42万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Development Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/nicotinamide-adenine-dinucleotide-oocyte-quality/946969
• 关键词: Nicotinamide; adenine; dinucleotide; NAD+; raising

Many women cannot have children because of suboptimal egg quality, often due to aging. Currently, the only option is to use better quality eggs donated from another woman. This project will use pharmacological agents to promote recently discovered pathways in eggs central to determining quality. Importantly, we will investigate a simple and practical approach that can be used in clinics for augmenting these pathways to improve oocyte quality for the first time.

许多女性因为卵子质量不佳而无法生育，这通常是由于年龄的原因。目前，唯一的选择是使用另一名女性捐赠的质量更好的卵子。该项目将使用药理学试剂来促进最近在鸡蛋中发现的决定质量的关键途径。重要的是，我们将研究一种简单而实用的方法，可以用于临床，以增强这些途径，以提高卵子质量首次。