Nicotinamide adenine dinucleotide (NAD+)-raising agents for improving oocyte quality

许多女性不能生育是因为卵子质量不佳，通常是由于衰老。目前，唯一的选择是使用另一名妇女捐赠的质量更好的卵子。该项目将使用药理学试剂来促进最近发现的鸡蛋中决定质量的关键途径。重要的是，我们将研究一种简单实用的方法，可用于临床，以增加这些途径，以提高卵母细胞的质量首次。

Many women cannot have children because of suboptimal egg quality, often due to aging. Currently, the only option is to use better quality eggs donated from another woman. This project will use pharmacological agents to promote recently discovered pathways in eggs central to determining quality. Importantly, we will investigate a simple and practical approach that can be used in clinics for augmenting these pathways to improve oocyte quality for the first time.