FGF-1 in human adipogenesis

FGF-1 在人类脂肪形成中的作用

• 批准号: nhmrc : 401528
• 负责人: Dr Louise Hutley
• 金额: $ 29.21万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/fgf-1-human-adipogenesis/81401
• 关键词: FGF; human; adipogenesis

Obesity is becoming more common in Australian adults and children, and is a major contributor to a number of diseases including type 2 diabetes, cardiovascular disease and some cancers. Current weight loss strategies using either lifestyle modification (diet and exercise) or drugs are relatively ineffective in the majority of obese individuals. This is partly due to the fact that we have an incomplete knowledge of the factors that regulate weight in humans. In laboratory studies we have shown that human fat cell development can be dramatically accelerated by fibroblast growth factor-1 (FGF-1). This growth factor is produced by human endothelial cells, which are cells that line the blood vessels in fat tissue. When human fat cell precursors (preadipocytes) are cultured in the presence of FGF-1 the preadipocytes divide much more rapidly than normal and, additionally, then develop into mature fat cells much more rapidly than normal. These processes involved in development of new fat cells form the basis of fat tissue expansion in the body. The effect of FGF-1 on human fat cell development is far greater in magnitude than that of other known factors that promote fat cell growth. The aim of this project is to determine the actual biochemical pathways that mediate the effect of FGF-1 in promoting fat cell growth and development. Results obtained will provide insight into the cellular and molecular mechanisms regulating expansion of fat tissue mass in humans. Research aimed at identifying these underlying mechanisms, or at potentially contributing or exacerbating factors, is critically important in development of novel and more effective approaches to prevention and treatment of obesity.

肥胖症在澳大利亚成人和儿童中越来越普遍，是导致包括2型糖尿病、心血管疾病和某些癌症在内的许多疾病的主要原因。目前的减肥策略，无论是生活方式的改变（饮食和运动）或药物是相对无效的大多数肥胖个体。这部分是由于我们对调节人类体重的因素的了解不完整。在实验室研究中，我们已经表明，人类脂肪细胞的发展可以显着加速成纤维细胞生长因子-1（FGF-1）。这种生长因子是由人类内皮细胞产生的，内皮细胞是脂肪组织中血管的细胞。当在FGF-1存在下培养人脂肪细胞前体（前脂肪细胞）时，前脂肪细胞比正常细胞分裂快得多，并且另外，然后比正常细胞发育成成熟脂肪细胞快得多。这些过程涉及新的脂肪细胞的发展形成的基础上脂肪组织扩张的身体。FGF-1对人类脂肪细胞发育的影响远远大于其他已知的促进脂肪细胞生长的因子。该项目的目的是确定介导FGF-1促进脂肪细胞生长和发育的实际生化途径。所获得的结果将提供深入了解的细胞和分子机制，调节人体脂肪组织质量的扩张。旨在确定这些潜在机制或潜在促成或加剧因素的研究对于开发预防和治疗肥胖的新的和更有效的方法至关重要。