ENOS Genotype, BP, and Exercise in African Americans

描述（由申请人提供）：候选人：候选人是一个运动生理学家谁的初步研究集中在胰岛素抵抗综合征和运动在非洲裔美国人（AA）高血压。候选人研究的独立性和复杂性在博士后培训和担任助理教授的前2年以上取得了进展。候选人是唯一有资格追求一个独立的研究职业ingene-exercise互动在老年机管局。 研究：高血压相关的发病率和死亡率在AA人群中是毁灭性的。许多基因位点的多态性变异与环境因素相互作用，影响BP。候选人的初步数据表明，内皮型一氧化氮（eNOS）基因型1影响血压（BP），肾血流动力学和外周血管对运动训练的反应。 因此，我们的假设是，共同的eNOS基因多态性将确定中年至老年AA高血压谁将改善他们的血压，肾血流动力学和外周血管功能最有氧运动训练。了解高血压AA中遗传决定的运动训练反应将导致更有效的HTN治疗。将根据eNOS基因型对50-70岁的久坐高血压AA男性和女性进行前瞻性筛选。受试者将完成饮食稳定期，然后进行肾血流动力学基线检查、肱动脉超声检查和24小时动态血压和尿液采集，随后进行6个月的运动训练和最终检查。 工作环境：收到这个KO 1和博士的指导Hagberg，Ferrell和Weir，将允许候选人在老年AA与高血压的基因运动相互作用中开始职业生涯。James Hagberg博士在对患有心血管疾病的老年人进行运动训练干预以及基因-运动相互作用方面具有专业知识。Matthew Weir博士在评估高血压AA的肾脏血流动力学方面具有专业知识。Robert Ferrell博士是基因在高血压和其他慢性疾病中的作用方面的专家。候选人将在丰富的研究培训环境中学习和工作，并提供高级培训资源，获得必要的技能和培训，以开始独立的研究生涯这一前沿研究领域。

DESCRIPTION (provided by applicant): Candidate: The candidate is an Exercise Physiologist who's initial research focused the Insulin Resistance Syndrome and exercise in African American (AA) hypertensives. The independence and complexity of the candidate's research has progressed during h s postdoctoral training and first 2+ yrs as an Assistant Professor. The candidate is uniquely qualified to pursue an independent research career ingene-exercise interaction in older AA. Research: Hypertension-related morbidity and mortality are devastating in the AA population. Polymorphic variations at many gene loci interact with environmental factors to affect BP. The candidate's preliminary data suggest that endothelial nitric oxide (eNOS) genotype l affects blood pressure (BP), renal hemodynamic, and peripheral vascular responses to exercise training. Thus, our Hypothesis is that common eNOS gene polymorphisms will identify middle-aged to older AA hypertensives who will improve their BP, renal hemodynamics, and peripheral vascular function the most with arobic exercise training. Knowledge of genetically determined exercise training responses in hypertensive AA will result in a more effective HTN treatment. Sedentary hypertensive AA men and women 50-70 yrs of age will be screened prospectively into groups based on their eNOS genotype. Subjects will complete a Dietary Stabilization period and then undergo Baseline Testing of renal hemodynamics, brachial artery ultrasound studies, and 24-hr ambulatory BP and urine collection, followed by 6 months of exercise training and Final Testing. Environment: Receipt of this KO1 and the mentoring of Drs. Hagberg, Ferrell and Weir, will allow the candidate to launch a career in gene-exercise interactions in older AA with hypertension. Dr. James Hagberg has expertise in administering exercise-training interventions in older individuals with cardiovascular disease and in gene-exercise interactions. Dr. Matthew Weir has expertise in assessing renal hemodynamics in hypertensive AA. Dr. Robert Ferrell is an expert in the role of genes in hypertension and other chronic diseases. The candidate will learn and work in a rich research training environment with resources for advanced training and gain the requisite skills and training to embark on independent research career this cutting-edge area of research.