AEROBIC EXERCISE AND BLOOD PRESSURE--META-ANALYSIS

有氧运动与血压——荟萃分析

• 批准号: 2464938
• 负责人: George A Kelley
• 金额: $ 7.05万
• 依托单位: NORTHERN ILLINOIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-01 至 2000-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2464938
• 关键词: adult human (21+); aerobic exercise; blood pressure; cardiovascular disorder epidemiology; cardiovascular disorder prevention; clinical research; human data; human therapy evaluation; hypertension; meta analysis

DESCRIPTION: (Adapted from Investigator's Abstract) Approximately 50 million Americans suffer from hypertension, a condition associated with increased risk for stroke, heart attack, and kidney failure. While non-pharmacological intervention has resulted in dramatic reductions in resting systolic and diastolic blood pressure for those with elevated pressures, a debate continues over the efficacy of pharmacological intervention because of deleterious side effects. As a result, there has been an increased interest in aerobic exercise as a non-pharmacologic approach in treating hypertension. Recent reviews of literature have synthesized research using the 'traditional' approach (chronologically arranging and describing the studies, perhaps by sub-topic) which may result in subjective, non-replicable conclusions. Consequently, the relationships among such variables as subject characteristics, experimental design quality, training program characteristics, and how they contribute to changes in resting systolic and diastolic blood pressure is not clear. In this proposed project, the meta-analytic approach will be used to synthesize research on the relationships among variables associated with aerobic exercise intervention and resting systolic and diastolic blood pressure in adults. Meta-analysis is a method of pooling the results of separate studies. It is a quantitative approach for increasing statistical power of primary end points and subgroups, resolving uncertainty when studies disagree, improving estimates of effect sizes, and answering questions not posed at the start of individual trials. To date, no recent study has quantitatively synthesized the existing literature regarding the role of aerobic exercise as a non-pharmacologic therapy in reducing resting systolic and diastolic blood pressure among adults. The purpose of this study is to use the meta-analytic approach to examine the effects of aerobic exercise on resting systolic and diastolic blood pressure in adults. The investigators point out that the results of this project should provide a clarification of the role of aerobic exercise as a non-pharmacologic intervention for reducing resting systolic and diastolic blood pressure in adults.

描述：（改编自研究者摘要）约50 100万美国人患有高血压，这是一种与 增加中风心脏病和肾衰竭的风险 而 非药物干预导致了 静息收缩压和舒张压升高者 压力下，关于药理学疗效的争论仍在继续。 因为有害的副作用。 因此， 作为一种非药物的有氧运动， 治疗高血压的方法。 最近的文献综述 采用“传统”方法进行综合研究（按时间顺序 安排和描述研究，也许按分专题）， 主观的不可复制的结论 因此，关系 在受试者特征、实验设计等变量中 质量，培训计划的特点，以及它们如何有助于 静息收缩压和舒张压的变化尚不清楚。 在 这个拟议的项目，元分析方法将被用来综合 有氧运动相关变量间关系的研究 运动干预与静息收缩压和舒张压的关系 成年人了 荟萃分析是一种将单独的结果汇总的方法。 问题研究 这是一种定量方法，用于增加 主要终点和亚组，解决研究时的不确定性 不同意，改善效应大小的估计，并回答问题， 在个别审判开始时提出的。 到目前为止，没有任何研究表明， 定量综合了现有文献中关于 有氧运动作为一种非药物疗法， 和成人的舒张压。 本研究的目的是 运用元分析方法研究有氧运动对 成年人的静息收缩压和舒张压。 调查人员 指出，该项目的结果应澄清 有氧运动作为一种非药物干预， 降低成年人的静息收缩压和舒张压。