ENOS Genotype, BP, and Exercise in African Americans

应聘者描述(申请人提供)：应聘者是一名运动生理学家，最初的研究重点是胰岛素抵抗综合征和非裔美国人(AA)高血压患者的运动。在S博士后培训和担任助理教授的头两年里，候选人研究的独立性和复杂性都有所提高。候选人是唯一有资格在老年AA中从事独立研究-运动互动的人。 研究：在AA人群中，高血压相关的发病率和死亡率是毁灭性的。许多基因座的多态变异与环境因素相互作用，从而影响血压。候选人的初步数据表明，内皮型一氧化氮合酶(ENOS)基因L影响血压、肾脏血流动力学和外周血管对运动训练的反应。 因此，我们的假设是，常见的eNOS基因多态性将识别中老年AA高血压患者，他们在无氧运动训练中改善血压、肾脏血流动力学和周围血管功能最好。了解高血压再生障碍性贫血的遗传决定的运动训练反应将导致更有效的HTN治疗。50-70岁的久坐高血压AA男性和女性将根据他们的eNOS基因被前瞻性地筛选成不同的组。受试者将完成饮食稳定期，然后接受肾血流动力学基线测试、臂动脉超声检查、24小时动态血压和尿液采集，然后进行6个月的运动训练和最终测试。 环境：收到这份KO1以及Hagberg、Ferrell和Weir博士的指导，将使候选人能够在患有高血压的老年再生障碍性贫血患者中开始基因-运动交互作用的职业生涯。詹姆斯·哈格伯格博士在对患有心血管疾病的老年人进行运动训练干预以及基因-运动相互作用方面拥有专业知识。Matthew Weir博士在评估高血压AA患者的肾脏血流动力学方面具有专业知识。罗伯特·费雷尔博士是高血压和其他慢性病中基因作用的专家。应聘者将在一个丰富的研究培训环境中学习和工作，拥有高级培训的资源，并获得必要的技能和培训，以开始这一前沿研究领域的独立研究生涯。

DESCRIPTION (provided by applicant): Candidate: The candidate is an Exercise Physiologist who's initial research focused the Insulin Resistance Syndrome and exercise in African American (AA) hypertensives. The independence and complexity of the candidate's research has progressed during h s postdoctoral training and first 2+ yrs as an Assistant Professor. The candidate is uniquely qualified to pursue an independent research career ingene-exercise interaction in older AA. Research: Hypertension-related morbidity and mortality are devastating in the AA population. Polymorphic variations at many gene loci interact with environmental factors to affect BP. The candidate's preliminary data suggest that endothelial nitric oxide (eNOS) genotype l affects blood pressure (BP), renal hemodynamic, and peripheral vascular responses to exercise training. Thus, our Hypothesis is that common eNOS gene polymorphisms will identify middle-aged to older AA hypertensives who will improve their BP, renal hemodynamics, and peripheral vascular function the most with arobic exercise training. Knowledge of genetically determined exercise training responses in hypertensive AA will result in a more effective HTN treatment. Sedentary hypertensive AA men and women 50-70 yrs of age will be screened prospectively into groups based on their eNOS genotype. Subjects will complete a Dietary Stabilization period and then undergo Baseline Testing of renal hemodynamics, brachial artery ultrasound studies, and 24-hr ambulatory BP and urine collection, followed by 6 months of exercise training and Final Testing. Environment: Receipt of this KO1 and the mentoring of Drs. Hagberg, Ferrell and Weir, will allow the candidate to launch a career in gene-exercise interactions in older AA with hypertension. Dr. James Hagberg has expertise in administering exercise-training interventions in older individuals with cardiovascular disease and in gene-exercise interactions. Dr. Matthew Weir has expertise in assessing renal hemodynamics in hypertensive AA. Dr. Robert Ferrell is an expert in the role of genes in hypertension and other chronic diseases. The candidate will learn and work in a rich research training environment with resources for advanced training and gain the requisite skills and training to embark on independent research career this cutting-edge area of research.