Locus coeruleus and processing of olfactory social cues

蓝斑和嗅觉社交线索的处理

• 批准号: 7113980
• 负责人: STEPHEN D SHEA
• 金额: $ 4.6万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7113980
• 关键词: arousal; attention; behavior test; behavioral /social science research tag; chemoreceptors; electrophysiology; ethology; granule cell; laboratory mouse; learning; locus coeruleus; memory; neural information processing; neural inhibition; neural plasticity; neural transmission; neuroregulation; norepinephrine; olfactions; olfactory lobe; pheromone; postdoctoral investigator; pyramidal cells; sex behavior; single cell analysis; social behavior; social perception; stimulus /response; urine

DESCRIPTION (provided by applicant): 'Bottom up' sensory representations are shaped by 'top down1 influences, such as behavioral state and attention. Mammalian olfaction has been a subject of intense interest since the discovery of its fundamental receptor units, but little is known about how receptor-based coding mechanisms interact with central feedback projections in the main olfactory bulb (MOB). The adrenergic locus coeruleus (LC) transmits information about arousal and attention. Norepinephrine (NE) plays a role in several olfactory learning behaviors and has known effects on MOB circuitry in vitro. This study will investigate how LC input shapes representations of individual identity carried by urine volatiles. Experiments will: 1) observe LC activity in awake mice during social olfactory interaction and learning 2.) test the specific lasting effects of LC activation on odor responses of MOB neurons and olfactory perception 3.) determine the cellular circuit mechanisms of this olfactory plasticity. These studies will provide a rare opportunity to examine the effects of arousal and attention on ethologically relevant perception. They are also generally relevant to mechanisms of cognitive flexibility and related pathologies such as attention deficit hyperactivity disorder.

描述（由申请人提供）：“自下而上”的感觉表示形式是由“ top down1的影响”（例如行为状态和注意力）所塑造的。自从发现其基本受体单元以来，哺乳动物的嗅觉一直是引起人们浓厚兴趣的主题，但是关于基于受体的编码机制如何与主要嗅球（MOB）中的中央反馈投影相互作用，知之甚少。肾上腺能基因座（LC）传递了有关唤醒和注意力的信息。去甲肾上腺素（NE）在几种嗅觉学习行为中起作用，并在体外对MOB电路具有已知影响。这项研究将研究LC输入形状如何通过尿液挥发物携带的个体身份表示。实验将：1）在社交嗅觉相互作用和学习过程中观察清醒小鼠的LC活性2.）测试LC激活对BOB神经元和嗅觉感知的气味反应的特定持久作用3.）确定该嗅觉可变性的细胞电路机制。这些研究将提供一个难得的机会来检查唤醒和关注对伦理上相关的感知的影响。它们通常也与认知灵活性的机制和相关病理（例如注意力缺陷多动障碍）有关。