Neuromodulation of auditory input

听觉输入的神经调节

• 批准号: 6516314
• 负责人: STEPHEN D SHEA
• 金额: $ 3.02万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6516314
• 关键词: acetylcholine; auditory feedback; electrophysiology; neural information processing; neural transmission; neuroregulation; predoctoral investigator; prosencephalon; songbirds

DESCRIPTION (provided by applicant): Songbird vocal learning provides an excellent model system in which to study the relationship of brain and behavior. Electrophysiological data from freely behaving birds suggest that behavioral state is relevant to song maintenance. Auditory feedback, which is necessary for the maintenance of song, is differentially regulated in two functionally and anatomically distinct pathways of the forebrain song system according to behavioral state. Our proposal aims to combine in vivo and in vitro electrophysiological techniques to examine the specific effects of cholinergic input on the transmission of auditory feedback in a forebrain nucleus which is a nexus of auditory and premotor activity. Cholinergic systems have been shown to be related to attention, arousal, and memory in a number of organisms, including humans. This series of experiments will therefore have the potential to illuminate the role of feedback and attentional mechanisms in the performance of complex motor behaviors.

描述（由申请人提供）：鸣禽声音学习提供了 出色的模型系统，可以研究大脑与行为的关系。 来自自由行为鸟类的电生理数据表明行为 状态与歌曲维护有关。听觉反馈，这是必需的 歌曲的维护，在两个功能上以差异性调节， 前脑歌曲系统的解剖学上不同的途径 行为状态。我们的建议旨在将体内和体外结合 电生理技术检查胆碱能的特定作用 在前脑核中传播听觉反馈的输入，这是一个 听觉和前活动的联系。胆碱能系统已显示为 与许多生物的关注，唤醒和记忆有关，包括 人类。因此，这一系列实验将有可能 阐明反馈和注意机制在表现中的作用 复杂的运动行为。