The fabrication of complex structures using biodegradable polymerised high internal phase emulsion (PolyHIPE) scaffolds for targeted drug delivery

使用可生物降解的聚合高内相乳液 (PolyHIPE) 支架制造复杂结构，用于靶向药物输送

• 批准号: 2729103
• 金额: --
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2729103
• 关键词: fabrication; complex; structures; using; biodegradable

There are a variety of unmet clinical needs in oral medicine that would benefit from direct delivery of therapeutic molecules to a specific site, including medication induced osteonecrosis of the jaw (MRONJ). This condition leads to the development lesions in oral soft tissues that expose the underlying bone, which is then infected by a range of pathogenic microorganisms, causing pain and reducing quality of life. These lesions are effectively untreatable, and current work in the School of Clinical Dentistry has been directed at the fabrication of prostheses to protect the site from further injury. The aim of this project is to advance this research beyond protection to delivery of therapeutic agents to eliminate the infection and promote tissue regeneration. The supervisors have recently developed a number of biodegradable porous materials based on polyHIPEs, and demonstrated that it is suitable for additive manufacturing to create complex/custom shapes. In previous work we produced polyHIPE microspheres for bone tissue engineering and we have also combined polyHIPEs with electrospinning to produce a guided bone regeneration membrane. This biomaterial system provides a very high surface area:volume ratio on account of the generation of a highly microporous surface using a polyHIPE approach, and it is biocompatible and already used in bulk in medical applications.

在口腔医学中，有许多未得到满足的临床需求将受益于将治疗分子直接输送到特定部位，包括药物诱导的颌骨骨坏死(MRONJ)。这种情况会导致口腔软组织的发育损害，暴露出下面的骨骼，然后被一系列致病微生物感染，导致疼痛和生活质量下降。这些损害实际上是无法治疗的，临床牙科学院目前的工作主要是制造假体，以保护局部免受进一步伤害。该项目的目的是将这项研究从保护发展到提供治疗剂，以消除感染并促进组织再生。监管人员最近开发了一些基于聚HIPE的可生物降解的多孔材料，并证明了它适合于添加制造来创建复杂/定制的形状。在以前的工作中，我们制备了用于骨组织工程的聚HIPE微球，我们还将聚HIPE与静电纺丝结合起来，制备了一种引导骨再生膜。这种生物材料系统提供了非常高的表面积：体积比，因为使用PolyHIPE方法生成了高度微孔的表面，并且它是生物兼容的，已经在医疗应用中大量使用。