Prefrontal Cortex Contributions to Behavior Organization

前额叶皮层对行为组织的贡献

• 批准号: 7112521
• 负责人: Erin L Rich
• 金额: $ 4.25万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-29 至 2010-05-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7112521
• 关键词: behavioral /social science research tag; electrophysiology; laboratory rat; learning; neural information processing; neurophysiology; neuropsychology; predoctoral investigator; prefrontal lobe /cortex

DESCRIPTION (provided by applicant): The overall goal of this proposal is to understand how the prefrontal cortex contributes to the organization of behavior. Prefrontal cortical pathology may be linked to symptoms of disorganized behavior in schizophrenia or obsessive-compulsive disorder. Here, behavioral organization and the role of the prelimbic/infralimbic (PL/IL) region of the rat prefrontal cortex will be investigated. The PL/IL is necessary for rats to learn a new strategy in the same environment where an old strategy was previously successful. This proposal hypothesizes that the PL/IL is also required to use two previously learned strategies flexibly. Rats will be taught to solve a maze using one strategy, then the PL/IL will be inactivated while the rats learn a second strategy or use two familiar strategies flexibly. Electrophysiological recordings of PL/IL neurons will be taken from rats performing the same PL/IL dependent tasks. Behavioral and task correlates of PL/IL activity will suggest how these neurons encode information and how the PL/IL contributes to the organization of flexible behavior. By understanding normal function in prefrontal cortical regions, we may begin to understand how dysfunction is related to disease.

描述（由申请人提供）：本提案的总体目标是了解前额叶皮层如何促进行为的组织。前额叶皮质病变可能与精神分裂症或强迫症的行为紊乱症状有关。在这里，行为组织和前边缘/边缘下（PL/IL）区域的大鼠前额皮质的作用将进行研究。PL/IL对于大鼠在旧策略先前成功的相同环境中学习新策略是必要的。这个建议假设PL/IL也需要灵活地使用两个以前学到的策略。将教导大鼠使用一种策略解决迷宫，然后PL/IL将被灭活，而大鼠学习第二种策略或灵活地使用两种熟悉的策略。PL/IL神经元的电生理记录将取自执行相同PL/IL依赖性任务的大鼠。PL/IL活动的行为和任务相关性将表明这些神经元如何编码信息以及PL/IL如何有助于灵活行为的组织。通过了解前额叶皮层区域的正常功能，我们可能开始了解功能障碍与疾病的关系。