MINORITY PREDOCTORAL FELLOWSHIP PROGRAM

少数族裔博士前奖学金计划

• 批准号: 7113733
• 负责人: JENNIFER K HO-CHEN
• 金额: $ 2.93万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-06 至 2007-07-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7113733
• 关键词: female; laboratory mouse; laboratory rat; predoctoral investigator; pregnancy; pregnancy circulation; pregnancy immunology; prolactin; trophoblast; uterus

DESCRIPTION (provided by applicant): "No thesis selected". My research interests are in understanding the regulation and function of trophoblast invasion as well as the maternal adaptations that occur during pregnancy. Studies will be done to better understand the relationship between trophoblast cells and the maternal vasculature, cells of the immune system, and prolactin family members. By deciphering how trophoblast invasion into the uterus is regulated, and what causes their disappearance, more can be discovered about the maternal-fetal environment during pregnancy. The significance of focusing on trophoblast invasion is to better understand and potentially prevent pregnancy-associated conditions such as pre-eclampsia and intrauterine growth restriction. Both are correlated with shallow trophoblast invasion and lead to pathologies in the mother and fetus.

描述（由申请人提供）：“没有论文选择”。 我的研究兴趣是了解滋养层细胞入侵的调节和功能，以及怀孕期间发生的母体适应。将进行研究，以更好地了解滋养层细胞和母体血管系统，免疫系统细胞和催乳素家族成员之间的关系。通过破译滋养层细胞如何侵入子宫，以及导致其消失的原因，可以发现更多关于怀孕期间母胎环境的信息。关注滋养层浸润的意义在于更好地理解和预防妊娠相关疾病，如先兆子痫和宫内生长受限。两者都与滋养层细胞的浅侵入有关，并导致母亲和胎儿的病理。