Unravelling the structures of molecules contained within complex mixtures

揭示复杂混合物中分子的结构

• 批准号: 2734402
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2734402
• 关键词: Unravelling; structures; molecules; contained; within

Mixtures are found everywhere from food and drink, manufacturing to our natural environment. Many contain unknown molecules or are so complex that standard chromatographic methods fail to separate individual molecules contained within them. Typically, identification of only a handful of compounds is possible and a large number of unknown compounds prevents structure-function relationships to be explored. This project aims to develop approaches to combine chromatographic separation ad high-end analytical techniques to elucidate structure of unknown compounds using NMR spectroscopy, HPLC-FT-ICR-MS and GC-GC-TOF-MS. The project will explore application of existing methods and develop new methodologies using a range of mixtures from peat organic matter to Scotch whisky.

混合物随处可见，从食品和饮料，制造业到我们的自然环境。许多含有未知分子或非常复杂，以至于标准色谱方法无法分离其中所含的单个分子。通常情况下，只有少数化合物的鉴定是可能的，大量的未知化合物阻止了结构-功能关系的探索。该项目旨在开发将联合收割机色谱分离和高端分析技术相结合的方法，以使用NMR光谱、HPLC-FT-ICR-MS和GC-GC-TOF-MS来阐明未知化合物的结构。该项目将探索现有方法的应用，并开发使用从泥炭有机物到苏格兰威士忌的一系列混合物的新方法。