CIS Research Consortium (CISRC): Years 2006-2011

CIS 研究联盟 (CISRC)：2006-2011 年

• 批准号: 7137965
• 负责人: ALFRED C MARCUS
• 金额: $ 214.82万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7137965
• 关键词: clinical research; interview; neoplasm /cancer

DESCRIPTION (provided by applicant): In this competitive renewal of the Cancer Information Service Consortium (CISRC) program project grant, two health communication interventions will be tested for efficacy across three groups of cancer patients who call the Cancer Information Service (1-800-4-CANCER): newly diagnosed prostate (Project 1) and breast (Project 2) cancer patients, and breast cancer patients at re-entry (Project 3). These two interventions include: 1) an innovative and highly interactive multimedia program, and 2) an equally innovative telephone callback intervention conducted by CIS Information Specialists. Both interventions share the common theme of helping these three target populations prepare for their on-going cancer experience (e.g. cancer-treatment decision-making and preparation for treatment, Projects 1 and 2; life after breast cancer, Project 3). Among enrolled participants who report access to a computer at baseline, all projects will share the same randomized three-group stepped design, where: Group 1 = usual service (+)standard print material; Group 2 = Group 1 (+) multimedia program; and Group 3 = Group 2 (+) a CIS telephone callback intervention interview at 7 days follow-up. Among enrolled participants who do not report access to a computer at baseline, all projects will share the same two-group design that will be conducted as a feasibility study pursuant to a future randomized trial, where Group 1A = same as Group 1above; Group 2A = Group 1A (+) a CIS callback intervention interview. Hypothesis-driven mediational and outcome analyses will be based on telephone interviews at 2-, 6-, and 12-months follow-up. Innovative cross-project exploratory analyses are also proposed for a core set of shared outcome resources, which will be the first of their kind across an extended segment of the cancer survivorship continuum. This is a resubmission of an earlier application that has benefited greatly from several revisions prompted by the concerns of the previous review committee. Supporting each project will be the following core resources: Administrative Core, Intervention Development and Measurement Core (IDMC), Survey Methods Core (SMC), and the Biostatistical Core (BC). By collaborating with all regional call centers of the CIS, the CISRC will mobilize the premiere cancer information program in the nation, with an unprecedented opportunity to conduct these three trials simultaneously with ample statistical power, and with significant potential for dissemination.

描述（由申请人提供）：在癌症信息服务联盟（CISRC）计划项目赠款的竞争性更新中，将在三组致电癌症信息服务的癌症患者中测试两种健康传播干预措施的有效性。（1-800-4-CANCER）：新诊断的前列腺癌（项目1）和乳腺癌（项目2）患者，以及重新入组时的乳腺癌患者（项目3）。这两项干预措施包括：1）创新和高度互动的多媒体节目，2）同样创新的电话回拨干预由CIS信息专家进行。这两项干预措施的共同主题是帮助这三个目标人群为他们正在经历的癌症做好准备（例如，癌症治疗决策和治疗准备，项目1和2;乳腺癌后的生活，项目3）。在基线时报告使用计算机的入组受试者中，所有项目将采用相同的随机三组阶梯设计，其中：第1组=常规服务（+）标准打印材料;第2组=第1组（+）多媒体程序;第3组=第2组（+）7天随访时的CIS电话回访干预访谈。在基线时未报告使用计算机的入组受试者中，所有项目将采用相同的两组设计，根据未来的随机试验进行可行性研究，其中组1A =与上述组1相同;组2A =组1A（+）CIS回调干预访谈。假设驱动的中介和结局分析将基于2个月、6个月和12个月随访时的电话访谈。创新的跨项目探索性分析也提出了一套核心的共享成果资源，这将是第一个跨癌症生存连续体的扩展部分。这是一个重新提交的较早的应用程序，大大受益于前审查委员会的关注所引发的几次修改。支持每个项目的将是以下核心资源：行政核心、干预开发和测量核心（IDMC）、调查方法核心（SMC）和生物统计核心（BC）。通过与独联体的所有区域呼叫中心合作，CISRC将动员全国首屈一指的癌症信息计划，提供前所未有的机会，以充分的统计能力同时进行这三项试验，并具有显著的传播潜力。