CIS Research Consortium (CISRC): Years 2006-2011

描述（由申请人提供）：在癌症信息服务联盟（CISRC）项目资助的竞争性更新中，将对三组拨打癌症信息服务（1-800-4- Cancer）的癌症患者：新诊断的前列腺癌（项目1）和乳腺癌（项目2）患者以及重新进入的乳腺癌患者（项目3）进行两种健康沟通干预措施的有效性测试。这两种干预措施包括：1)创新和高度互动的多媒体程序，以及2)由CIS信息专家进行的同样创新的电话回呼干预。这两种干预措施都有一个共同的主题，即帮助这三个目标人群为他们正在经历的癌症经历做好准备（例如，癌症治疗决策和治疗准备，项目1和2；乳腺癌后的生活，项目3）。在报告在基线时使用计算机的注册参与者中，所有项目将共享相同的随机三组阶梯设计，其中：第一组=常规服务（+）标准印刷材料；组2 =组1（+）多媒体节目；第3组=第2组（+）在随访7天进行CIS电话回调干预访谈。在未报告基线时使用计算机的入组参与者中，所有项目将共享相同的两组设计，作为未来随机试验的可行性研究，其中1A组=与上述1组相同；2A组= 1A组（+）一次CIS回调干预访谈。假设驱动的中介和结果分析将基于2个月、6个月和12个月随访时的电话访谈。创新的跨项目探索性分析还提出了一组共享结果资源的核心，这将是第一个跨越癌症生存连续体的扩展部分的此类分析。这是对先前申请的重新提交，该申请因前一次审查委员会的关切而进行了几次修订，大大受益。支持每个项目的核心资源包括：行政核心、干预发展和测量核心（IDMC）、调查方法核心（SMC）和生物统计核心（BC）。通过与CIS所有区域呼叫中心的合作，CISRC将动员全国首屈一指的癌症信息项目，以前所未有的机会同时进行这三个试验，具有充分的统计力量和巨大的传播潜力。

DESCRIPTION (provided by applicant): In this competitive renewal of the Cancer Information Service Consortium (CISRC) program project grant, two health communication interventions will be tested for efficacy across three groups of cancer patients who call the Cancer Information Service (1-800-4-CANCER): newly diagnosed prostate (Project 1) and breast (Project 2) cancer patients, and breast cancer patients at re-entry (Project 3). These two interventions include: 1) an innovative and highly interactive multimedia program, and 2) an equally innovative telephone callback intervention conducted by CIS Information Specialists. Both interventions share the common theme of helping these three target populations prepare for their on-going cancer experience (e.g. cancer-treatment decision-making and preparation for treatment, Projects 1 and 2; life after breast cancer, Project 3). Among enrolled participants who report access to a computer at baseline, all projects will share the same randomized three-group stepped design, where: Group 1 = usual service (+)standard print material; Group 2 = Group 1 (+) multimedia program; and Group 3 = Group 2 (+) a CIS telephone callback intervention interview at 7 days follow-up. Among enrolled participants who do not report access to a computer at baseline, all projects will share the same two-group design that will be conducted as a feasibility study pursuant to a future randomized trial, where Group 1A = same as Group 1above; Group 2A = Group 1A (+) a CIS callback intervention interview. Hypothesis-driven mediational and outcome analyses will be based on telephone interviews at 2-, 6-, and 12-months follow-up. Innovative cross-project exploratory analyses are also proposed for a core set of shared outcome resources, which will be the first of their kind across an extended segment of the cancer survivorship continuum. This is a resubmission of an earlier application that has benefited greatly from several revisions prompted by the concerns of the previous review committee. Supporting each project will be the following core resources: Administrative Core, Intervention Development and Measurement Core (IDMC), Survey Methods Core (SMC), and the Biostatistical Core (BC). By collaborating with all regional call centers of the CIS, the CISRC will mobilize the premiere cancer information program in the nation, with an unprecedented opportunity to conduct these three trials simultaneously with ample statistical power, and with significant potential for dissemination.