An 'unconventional' approach to the COVID 19 pandemic: the role of T cells in virus recognition
应对 COVID 19 大流行的“非常规”方法:T 细胞在病毒识别中的作用
基本信息
- 批准号:2734802
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:英国
- 项目类别:Studentship
- 财政年份:2022
- 资助国家:英国
- 起止时间:2022 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
TBCThis dynamic project will bring together two established groups to investigate the potentially crucial role of non-conventional immune responses to SARS-CoV-2. The response to the COVID19 pandemic has been rapid and has led to the successful development of vaccines that target the viral Spike protein. Whilst this has had a substantial impact on COVID19, it is has also highlighted that the specificity of Spike-based vaccines might also be their Achilles heel. Indeed, sustained world-wide virus transmission has resulted in the emergence of variants that can render the vaccine programmes ineffective due to mismatch between the circulating Spike sequences and those used for the vaccines. It is therefore crucial to investigate strategies that are independent of virus sequences. This exciting project will investigate the potential of the innate immune response against viral diseases and how unconventional T cells (i.e. T cell) respond rapidly to infected cells by recognising 'danger signals' expressed by these cells. In particular, the project asks three related but free-standing questions: 1. What are the signals on the infected cells that trigger this fast "detection and kill" approach by unconventional T cells? 2. What are the molecular mechanisms that unravel within unconventional T cells to generate that "detection and kill" approach? 3. Are danger signals and responses present in tissues from SARS-CoV-2 infected non-human primates? The project will require a wide range of techniques including cell culture (cell lines; primary cells), flow-cytometry, western blotting; work with replication competent SARS-CoV-2 (BSL3 containment laboratory at SGUL). Immunohistochemistry and in situ hybridisation of SARS-CoV-2 non-human primate tissues will be undertaken at the Comparative Pathology team at UK Health Security Agency (Porton Down), where the successful applicant will be expected to spend 3 months (placement). This project suits a self-motivated person with a strong will to learn and deliver. You will have a strong interest in immunology and its impact in global health, coupled with a pro-active attitude to problem-solving.
他的动态项目将把两个既定的小组聚集在一起,研究针对SARS-CoV-2的非常规免疫反应的潜在关键作用。对COVID19大流行的反应迅速,并导致成功开发了针对病毒Spike蛋白的疫苗。虽然这对COVID19产生了重大影响,但也突显了基于Spike的疫苗的特异性可能也是它们的致命弱点。事实上,世界范围内持续的病毒传播导致了变种的出现,这些变种可能会由于流通中的尖峰序列与用于疫苗的序列不匹配而使疫苗计划无效。因此,研究独立于病毒序列的策略是至关重要的。这个令人兴奋的项目将研究针对病毒疾病的先天免疫反应的潜力,以及非传统T细胞(即T细胞)如何通过识别这些细胞表达的“危险信号”来对感染细胞做出快速反应。特别是,该项目提出了三个相关但独立的问题:1.感染细胞上的哪些信号触发了非常规T细胞的这种快速“检测并杀死”方法?2.非传统T细胞内解体产生这种“检测并杀死”方法的分子机制是什么?3.感染SARS-CoV-2的非人类灵长类动物的组织中是否存在危险信号和反应?该项目将需要广泛的技术,包括细胞培养(细胞系;原代细胞)、流式细胞术、免疫印迹;与具有复制能力的SARS-CoV-2(SGUL的BSL3遏制实验室)合作。SARS-CoV-2非人类灵长类组织的免疫组织化学和原位杂交将在英国卫生安全局(Porton Down)的比较病理小组进行,成功的申请者将在那里度过3个月(安置)。这个项目适合有强烈学习和交付意愿的自我激励的人。你将对免疫学及其对全球健康的影响产生浓厚的兴趣,并对解决问题持积极主动的态度。
项目成果
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其他文献
Internet-administered, low-intensity cognitive behavioral therapy for parents of children treated for cancer: A feasibility trial (ENGAGE).
针对癌症儿童父母的互联网管理、低强度认知行为疗法:可行性试验 (ENGAGE)。
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10.1002/cam4.5377 - 发表时间:
2023-03 - 期刊:
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Differences in child and adolescent exposure to unhealthy food and beverage advertising on television in a self-regulatory environment.
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- DOI:
10.1186/s12889-023-15027-w - 发表时间:
2023-03-23 - 期刊:
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The association between rheumatoid arthritis and reduced estimated cardiorespiratory fitness is mediated by physical symptoms and negative emotions: a cross-sectional study.
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- DOI:
10.1007/s10067-023-06584-x - 发表时间:
2023-07 - 期刊:
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ElasticBLAST: accelerating sequence search via cloud computing.
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10.1186/s12859-023-05245-9 - 发表时间:
2023-03-26 - 期刊:
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Amplified EQCM-D detection of extracellular vesicles using 2D gold nanostructured arrays fabricated by block copolymer self-assembly.
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- DOI:
10.1039/d2nh00424k - 发表时间:
2023-03-27 - 期刊:
- 影响因子:9.7
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的其他文献
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{{ truncateString('', 18)}}的其他基金
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