Washington University Center for Translational Neuroscience

华盛顿大学转化神经科学中心

• 批准号: 7321060
• 负责人: CHARLES F ZORUMSKI
• 金额: $ 23.01万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-25 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7321060
• 关键词: behavior; human; model; pain; university

The ability to translate discoveries in basic neurobiology from rodent models to humans requires careful phenotypic assessment. Many, if not all, human neuropsychiatric disorders involve significant changes in behavior, sensorimotor processing and synaptic function. While great progress is being made in generating rodent models of neuropsychiatric disorders, including genetic models in transgenic mice, the ability to characterize these models systematically at behavioral and synaptic levels has lagged and has often not been integrated across scientific disciplines. We propose to create a Functional Assessment Core (FAC) that will address these issues and facilitate translational research in the broader Washington University (WU) neuroscience community. This core will draw upon existing expertise in several WU departments, including Psychiatry, Neurology, Otolaryngology and Anesthesiology, and will provide analyses of rodent behavior, sensory function and pain processing in combination with in vivo and in vitro studies of synaptic function. The specific aims of the FAC are: 1. To provide assessment of rodent behavior, including learning and memory, emotionality, sensorimotor capabilities and social interactions, pain-related behaviors, and sensory function; 2. To provide assessment of synaptic function in rodent models using physiological approaches that range from in vivo electroencephalography and evoked potential studies to in vitro brain slice preparations and single-synapse studies in dissociated cell culture; and 3. To provide scientific expertise and management skills necessary for promoting easy access to functional assessment research and for maintaining an efficient core facility to carry out such work. Client-based services associated with this aim include consultation in designing studies, in presenting and interpreting data, in conducting appropriate statistical analyses, and in database management, access, and archiving in association with the Administrative and Informatics Cores. The FAC is designed to serve as a bridge between target discovery and characterization (via the Molecular Analysis, Optical Imaging and Viral Vector Cores) and translational efforts in the Biospecimen and Clinical Data Acquisition Core. In turn, the FAC will serve as a conduit for integration with other existing translational research efforts at WU including programs in neuroimaging, human neurogenetics and neuroclinical trials.

将基础神经生物学的发现从啮齿动物模型转化为人类的能力需要仔细 表型评估。许多（如果不是全部）人类神经精神疾病都涉及显着的变化 行为、感觉运动处理和突触功能。虽然在生成方面取得了巨大进展 神经精神疾病的啮齿动物模型，包括转基因小鼠的遗传模型， 在行为和突触水平上系统地表征这些模型已经滞后并且通常没有 已跨科学学科整合。我们建议创建功能评估核心（FAC） 这将解决这些问题并促进更广泛的华盛顿大学（WU）的转化研究 神经科学界。该核心将利用西弗吉尼亚大学多个部门的现有专业知识，包括 精神病学、神经病学、耳鼻喉科和麻醉学，并将提供啮齿动物行为分析， 感觉功能和疼痛处理与突触功能的体内和体外研究相结合。 FAC 的具体目标是： 1. 提供啮齿动物行为评估，包括学习和行为 记忆、情绪、感觉运动能力和社交互动、疼痛相关行为和感觉 功能; 2. 使用生理学方法对啮齿动物模型中的突触功能进行评估 范围从体内脑电图和诱发电位研究到体外脑切片制备 和分离细胞培养中的单突触研究； 3. 提供科学专业知识和 促进轻松获得功能评估研究和促进功能评估研究所需的管理技能 维持高效的核心设施来开展此类工作。与此目标相关的基于客户的服务 包括设计研究、呈现和解释数据、进行适当的咨询 统计分析，以及与数据库相关的管理、访问和归档 行政和信息学核心。 FAC 旨在充当目标发现之间的桥梁 和表征（通过分子分析、光学成像和病毒载体核心）和转化 在生物样本和临床数据采集核心方面的努力。反过来，FAC 将充当一个渠道： 与 WU 现有的其他转化研究工作相整合，包括神经影像学项目、 人类神经遗传学和神经临床试验。