CORE--IMAGE ACQUISTION & ANALYSIS

描述(由申请者提供)：请支持我们在俄克拉荷马大学健康科学中心(OUHSC)继续发放我们的NEI视力中心助学金。提出了四个模块：图像获取与分析、动物资源、生物信息学/蛋白质组学和分子生物学。这些单元为NIH资助的20名调查人员提供了基本服务，并提供了14笔符合NEI资格的赠款。图像和动物模块位于Dean A.McGee眼科研究所(DMEI)，翻新后的设施包括2000平方英尺的核心模块和12000平方英尺的研究实验室。后两个位于细胞生物学和生物化学与分子生物学系新装修的生物医学大楼(BMSB)。所有模块和研究实验室都在彼此三个街区的范围内。自上次提交以来，由NEI资助的9名调查人员已被招募到眼科和细胞生物学系。核心支持的可获得性是我们快速增长的主要贡献。这四个核心模块将通过为核心人员提供稳定、集中的服务来提高OUHSC的VISION研究活动的生产率。这些单元将通过提供允许采用多学科方法的资源来促进和加强资助的项目；促进试点研究的启动；促进研究人员之间的合作研究项目；帮助OUHSC招聘其他视觉研究人员；为校园内的研究人员提供机会，与视觉核心中心调查人员合作发起视觉研究项目；以及为研究生提供资源 以及视觉研究实验室的博士后研究员。教务长、经济、社会和文化事务部以及眼科和细胞生物系的机构支助将提供实验室空间；实验室空间翻新资金；对核心模块的部分支助，包括用于新仪器和核心人员工资的匹配资金；对教员工资的部分支助；以及未来4年招聘2名新教员的薪金和启动资金。这种基础广泛的机构支持将确保每个核心模块配备和供应，以完全服务于OUHSC视觉研究人员的需求。

DESCRIPTION (provided by applicant): Support is requested for continuation of our NEI Vision Center Grant at the University of Oklahoma Health Sciences Center (OUHSC). Four Modules are proposed: Image Acquisition and Analysis, Animal Resources, Bioinformatics/Proteomics, and Molecular Biology. These modules provide essential services to 20 NIH-funded investigators with 14 NEI-eligible grants. The Image and Animal Modules are located in the Dean A. McGee Eye Institute (DMEI) in renovated facilities that include 2,000 square feet for the core modules and 12,000 square feet for research laboratories. The latter two are located in the Biomedical Sciences Building (BMSB) in newly renovated space in the Departments of Cell Biology and Biochemistry & Molecular Biology. All modules and research laboratories are within three blocks of each other. Since the last submission, 9 NEI-funded investigators have been recruited into the Departments of Ophthalmology and Cell Biology. The availability of core support is a major contributor to our rapid growth. These four core modules will increase productivity of the vision research activities at the OUHSC by providing stable, centralized services with core personnel. The modules will promote and enhance funded projects by providing resources that allow multidisciplinary approaches; facilitate the initiation of pilot studies; promote collaborative research projects between investigators; aid in the recruitment of other vision researchers to the OUHSC; provide opportunities for researchers on campus to initiate vision research projects, in collaboration with vision Core Center investigators; and provide resources for graduate students and postdoctoral fellows in vision research laboratories. Institutional support from the provost, DMEI, and the Departments of Ophthalmology and Cell Biology will provide laboratory space; funds for renovation of laboratory space; partial support for core modules, including matching funds for new instruments and core personnel salaries; partial support for faculty salaries; and salaries and start-up funds for the recruitment of 2 new faculty members over the next 4 years. This broad-based institutional support will ensure that each Core Module is staffed and supplied to completely serve the needs of vision researchers at the OUHSC.