Intratreatment monitoring of prostate movement during r*

治疗期间 r* 期间前列腺运动监测

• 批准号: 6937008
• 负责人: HOWARD M SANDLER
• 金额: $ 22.19万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-27 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6937008
• 关键词: clinical research; prostate

DESCRIPTION (provided by applicant): This proposal seeks to facilitate radiation therapy for patients with prostate cancer. Recent studies have demonstrated that increasing radiation dose improves the likelihood of disease control of prostate cancer. The current doses under evaluation (70 to 80 Gy) are associated with potentially significant risk of toxicity to the normal organs adjacent to the prostate, especially the rectum. Sparing the rectal wall from potentially toxic doses of radiation, while continuing to treat the peripheral zone of the prostate, involves precise treatment planning and delivery. Ensuring such precise treatment plans do not result in prostate gland underdosage has been only partly handled by pre-treatment localization. Intratreatment physiological movement of the prostate, although demonstrated to be potentially significant (i.e., up to 2 cm), has not yet been addressed clinically. Intratreatment target movement is greatest when patients are positioned prone for treatment, potentially decreasing an observed static advantage of geometric separation of the rectum from the prostate that occurs when patients are placed in the prone position. The hypothesis of this study is that intratreatment prostate movement limits the dose received by the prostate, and that monitoring and reducing this movement will provide increased rectal dose sparing, thus facilitating safe and accurate prostate gland treatment. Descriptive statistics of prostate movement will be acquired using a novel, minimally invasive system for monitoring implanted electromagnetic transponders. The specific aims are to determine the impact of movement on 1) dose to the prostate and 2) dose to the rectal wall. The data from this study will support a subsequent Phase II trial to establish tumor control as well as morbidity reduction in radiotherapy treatments monitored and controlled to minimize intratreatment prostate movement.

描述（由申请人提供）：本提案旨在促进前列腺癌患者的放射治疗。最近的研究表明，增加辐射剂量可以提高前列腺癌疾病控制的可能性。目前正在评估的剂量（70至80戈瑞）与前列腺附近正常器官，特别是直肠的潜在重大毒性风险有关。在继续治疗前列腺外周区域的同时，使直肠壁免受潜在毒性剂量的辐射，需要精确的治疗计划和交付。确保这种精确的治疗计划不会导致前列腺剂量不足，治疗前定位只是部分处理。治疗期间前列腺的生理运动，虽然被证明具有潜在的显著性（即高达2厘米），但尚未在临床上得到解决。当患者俯卧位时，治疗内靶标移动最大，这可能会降低观察到的直肠与前列腺几何分离的静态优势，当患者俯卧位时，这种优势会出现。本研究的假设是，治疗中前列腺运动限制了前列腺接受的剂量，监测和减少前列腺运动将增加直肠剂量节约，从而促进安全准确的前列腺治疗。前列腺运动的描述性统计数据将使用一种新型的微创系统来监测植入的电磁应答器。具体目的是确定运动对1)前列腺剂量和2)直肠壁剂量的影响。这项研究的数据将支持随后的II期试验，以建立肿瘤控制和发病率降低在放疗治疗中监测和控制，以尽量减少治疗内前列腺运动。