Low dose digital X-rays for mammographic screening

用于乳房 X 光检查的低剂量数字 X 射线

• 批准号: 7140094
• 负责人: CHRISTOPHER L VAUGHAN
• 金额: $ 11.6万
• 依托单位: UNIVERSITY OF CAPE TOWN
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7140094
• 关键词: breast neoplasms; clinical research; computer assisted diagnosis; diagnosis design /evaluation; digital imaging; female; human subject; image enhancement; mammography; radiation dosage; technology /technique development

DESCRIPTION (provided by applicant): Breast cancer currently accounts for 9% of all cancers worldwide, while in the United States 32% of cancer incidence and 18% of cancer deaths are a result of breast carcinoma. Although recent reports in the popular media have called into question the benefits of mammographic screening, the scientific literature is clear: early detection and treatment of breast cancer have yielded a 20% reduction in the mortality rate in the past decade. Despite the success of current screen-film mammography systems, which account for more than 95% of all units worldwide, they do suffer from a number of drawbacks. The long-term objective of this project is to address these drawbacks by developing a digital mammography system built on innovative medical imaging technologies that have been created in South Africa. Specifically, our aim is to develop a system with the following important features: (1) significantly lower radiation exposure for both patients and healthcare workers; (2) outstanding image quality verified by modulation transfer function (MTF) and detective quantum efficiency (DQE); (3) improved patient comfort through the reduction of painful breast compression; (4) greater coverage of breast anatomy, resulting in fewer missed diagnoses; (5) the provision of computer-assisted diagnosis (CAD) based on the digital images; and (6) reduced time spent in the exam room, leading to increased patient throughput. There will be two overlapping phases to the project. In phase 1, a prototype digital mammography system will be designed, built and tested. We will reduce radiation exposure while maintaining image quality by incorporating a patented slot scanning technique that has recently been approved for whole-body trauma applications by the Food and Drug Administration. Solid-state image sensors will be incorporated in the design of the X-ray detectors, maximizing the signal-to-noise ratio. A careful study of MTF and DQE will be conducted, in addition to manikin phantom studies to measure dose and detection of small lesions. By scanning in a motion that accounts for breast anatomy, it will be possible to improve patient comfort by reducing the need for breast compression and also covering a greater volume of breast tissue. Because the images will be in digital form, this will facilitate CAD applications while also reducing patient examination time. During the last 6 months of the project in phase 2, we will conduct a limited clinical trial of 20 patients, focusing on comfort, breast coverage and diagnostic equivalence.

描述（由申请人提供）： 目前乳腺癌占全球所有癌症的 9%，而在美国，32% 的癌症发病率和 18% 的癌症死亡都是由乳腺癌造成的。尽管大众媒体最近的报道对乳房X光检查的好处提出了质疑，但科学文献很明确：在过去十年中，乳腺癌的早期发现和治疗使死亡率降低了20%。尽管目前的屏幕胶片乳房X光检查系统取得了成功（占全球所有装置的95%以上），但它们确实存在许多缺点。该项目的长期目标是通过开发基于南非创建的创新医学成像技术的数字乳房X光检查系统来解决这些缺点。具体来说，我们的目标是开发一个具有以下重要特征的系统：（1）显着降低患者和医护人员的辐射暴露； （2）通过调制传递函数（MTF）和探测量子效率（DQE）验证的出色图像质量； (3) 通过减少乳房压迫疼痛来提高患者的舒适度； (4) 乳腺解剖覆盖面更大，漏诊率更低； (5) 提供基于数字图像的计算机辅助诊断(CAD)； (6) 减少在检查室停留的时间，从而提高患者的吞吐量。该项目将有两个重叠的阶段。在第一阶段，将设计、建造和测试原型数字乳腺X线摄影系统。我们将通过采用专利狭缝扫描技术来减少辐射暴露，同时保持图像质量，该技术最近已被美国食品和药物管理局批准用于全身创伤应用。固态图像传感器将被纳入 X 射线探测器的设计中，从而最大限度地提高信噪比。除了用于测量剂量和检测小病变的人体模型研究之外，还将对 MTF 和 DQE 进行仔细研究。通过考虑乳房解剖结构的运动进行扫描，可以减少乳房压迫的需要并覆盖更大体积的乳房组织，从而提高患者的舒适度。由于图像将采用数字形式，这将有利于 CAD 应用，同时还可以减少患者检查时间。在第二阶段项目的最后 6 个月内，我们将进行 20 名患者的有限临床试验，重点关注舒适度、乳房覆盖和诊断等效性。

项目成果

Modeling, validation and application of a mathematical tissue-equivalent breast phantom for linear slot-scanning digital mammography.

用于线性槽扫描数字乳房X线摄影的数学组织等效乳房模型的建模、验证和应用。

• DOI: 10.1088/0031-9155/54/6/009
• 发表时间: 2009
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Hussein,K;Vaughan,CL;Douglas,TS
• 通讯作者: Douglas,TS

Detecting Breast Cancer with a Dual-Modality Device.

使用双模态设备检测乳腺癌。

• DOI: 10.3390/diagnostics7010017
• 发表时间: 2017
• 期刊: Diagnostics (Basel, Switzerland)
• 作者: Padia,Kamila;Douglas,TaniaS;Cairncross,LydiaL;Baasch,RolandV;Vaughan,ChristopherL
• 通讯作者: Vaughan,ChristopherL

Testing a dual-modality system that combines full-field digital mammography and automated breast ultrasound.

测试结合全场数字乳房X线摄影和自动乳房超声的双模式系统。

• DOI: 10.1016/j.clinimag.2015.11.024
• 发表时间: 2016-05
• 期刊: Clinical imaging
• 影响因子: 2.1
• 作者: Vaughan CL;Douglas TS;Said-Hartley Q;Baasch RV;Boonzaier JA;Goemans BC;Harverson J;Mingay MW;Omar S;Smith RV;Venter NC;Wilson HS
• 通讯作者: Wilson HS