Immunologic/Genetic Mechanisms in Rheumatic Diseases

风湿性疾病的免疫/遗传机制

• 批准号: 7061646
• 负责人: WESTLEY H REEVES
• 金额: $ 18.49万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7061646
• 关键词: Immunologic; Genetic; Mechanisms; Rheumatic; Diseases

DESCRIPTION (provided by applicant): Postgraduate Rheumatology training programs are devoted largely to training young physicians in the clinical aspects of rheumatic diseases. There are only a handful of strong basic-science-oriented programs that consistently have produced high quality graduates equipped by their training experience for an academic career in teaching and research directed at key problems related to the connective tissue diseases. There is a particular need for biomedical scientists trained in disease-related clinical research. This goal of this research training program, now in its fifth year of funding, is to provide a broad investigational experience in laboratory and/or non-laboratory research related to the study of rheumatic diseases. The training program focuses on the immunology and genetics of autoimmunity, vasculitis, and the connective tissue diseases. Formal curricula as well as research focus groups provide a structure for the program. The program is designed to provide cross-fertilization between individuals with a basic science background and those with clinical training. Patient- and disease-oriented research is emphasized. The training of M.D. postdoctoral fellows who plan careers in academic rheumatology is an important objective. As in the past, both pre-doctoral candidates and postdoctoral fellows will select mentors from a diverse clinical and basic science faculty. Infrastructure for carrying out clinical research has been expanded considerably during the past three years and a strong link has been forged with the University's General Clinical Research Center. The ability to carry out patient-based research is enhanced by a large patient base and ongoing active research in systemic lupus erythematosus, Sjogren's syndrome, type I diabetes, and other autoimmune diseases along with financial support for these programs through the Centers for Autoimmune Diseases and Immunology & Transplantation. The training is largely preceptorial, with more than 75% of the trainee's time devoted to independent research activities. Ongoing animal and human biomedical research addresses many issues relevant to autoimmunity, vasculitis/vascular biology, arthritis, therapeutics (gene and stem cell therapy), and other forms of immunological disease, encompassing the fields of immunology, genetics, cell biology, biochemistry, epidemiology, and biostatistics. Faculty includes individuals from the basic sciences as well as clinical departments.

描述（由申请人提供）： 研究生风湿病学培训计划主要致力于培训年轻医生在风湿性疾病的临床方面。只有少数几个强大的基础科学为导向的计划，始终产生高质量的毕业生配备了他们的培训经验，在教学和研究的学术生涯针对有关结缔组织疾病的关键问题。特别需要在与疾病有关的临床研究方面受过训练的生物医学科学家。 这项研究培训计划的目标，现在在其第五年的资金，是提供广泛的研究经验，在实验室和/或非实验室研究有关的风湿性疾病的研究。该培训计划的重点是自身免疫，血管炎和结缔组织疾病的免疫学和遗传学。正式的课程以及研究重点小组提供了一个程序的结构。该计划旨在提供具有基础科学背景和临床培训的个人之间的交叉施肥。强调以病人和疾病为导向的研究。医学博士的培养计划从事学术流变学的博士后研究员是一个重要目标。与过去一样，博士前候选人和博士后研究员将从不同的临床和基础科学教师中选择导师。在过去三年中，开展临床研究的基础设施得到了极大的扩展，并与大学的综合临床研究中心建立了密切的联系。通过自身免疫疾病和免疫学与移植中心对系统性红斑狼疮、干燥综合征、I型糖尿病和其他自身免疫性疾病沿着的财政支持，大规模的患者基础和持续的积极研究增强了开展基于患者的研究的能力。培训主要是指导性的，学员75%以上的时间用于独立研究活动。正在进行的动物和人类生物医学研究解决了与自身免疫、血管炎/血管生物学、关节炎、治疗学（基因和干细胞治疗）以及其他形式的免疫性疾病相关的许多问题，涵盖免疫学、遗传学、细胞生物学、生物化学、流行病学和生物统计学领域。教师包括来自基础科学以及临床部门的个人。