Host-Microbe Interactions

宿主-微生物相互作用

• 批准号: 7108586
• 负责人: RONALD K TAYLOR
• 金额: $ 25.58万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7108586
• 关键词: Host; Microbe; Interactions

DESCRIPTION (provided by applicant): The primary goals of the proposed training program are first to recruit talented and highly motivated graduate students and postdoctoral fellows and second to provide them with first-rate training which will prepare them for careers in academic research as competitive, independent investigators. The program faculty's research interests span a wide range of questions regarding host-microbe interactions and related topics in pathogenesis, which allows the entering trainee a considerable breadth of choice of experimental systems, approaches, and research topics. Training options include animal and human systems, thus enhancing our ability to attract and train M.D.'s for research careers. Another strength of the proposed training grant is the quality of the research programs of the participating faculty. This proposal includes 13 well-funded program faculty members who have productive, timely, and energetic research efforts in numerous areas of current interest. Particular areas of strength are molecular genetics of bacterial, parasitic, and viral pathogenesis; cellular and immunobiology of parasites; B cell activation and interaction with T helper cells and lymphokines; mucosal immune responses; signaling events in host-pathogen interactions; involvement of various immune mechanisms in resistance to infectious diseases including those caused by parasites, bacteria, and retroviruses such as HIV and mouse AIDS (MAIDS) virus; immunotherapeutics and vaccine design. These areas are pursued using the full range of modem genetic, immunologic, biochemical, and molecular biologic techniques. We have excellent facilities, including new laboratories in the Borwell Research Building constructed in 1992. The proposal also benefits from the presence of strong existing graduate programs leading to the Ph.D. degree. Training in molecular pathogenesis spans six departments that encompass two graduate programs - Physiology, and Molecular and Cellular Biology - with the latter containing the majority of the participating faculty and students. Consistent with this organization, graduate training in molecular pathogenesis at Dartmouth is an interdisciplinary approach that is nurtured by a highly interactive environment in which the trainees are regularly exposed to diverse areas of faculty expertise, from clinical to basic science studies, in a variety of forums, including a number of advanced courses, weekly seminar series and journal clubs, and retreats. By these means our trainees benefit from a vigorous faculty involvement and scientific exchange that results in maximized communication of their work, the program faculty's work, and the progress of the various interdisciplinary fields on the international level.

描述(由申请者提供)：建议的培训计划的主要目标是首先招募有才华和高度积极的研究生和博士后研究员，其次为他们提供一流的培训，为他们在学术研究中的职业生涯做好准备，成为有竞争力的独立研究人员。该项目教师的研究兴趣涵盖了关于宿主-微生物相互作用的广泛问题和发病机制中的相关主题，这使得进入培训的学生有相当广泛的实验系统、方法和研究主题的选择。培训选项包括动物和人类系统，从而增强了我们吸引和培训S医学博士从事研究职业的能力。拟议的培训补助金的另一个优势是参与的教职员工的研究计划的质量。这项提案包括13名资金充足的项目教员，他们在当前感兴趣的许多领域做出了富有成效、及时和充满活力的研究努力。特别的优势领域是细菌、寄生虫和病毒致病的分子遗传学；寄生虫的细胞和免疫生物学；B细胞激活以及与T辅助细胞和淋巴因子的相互作用；粘膜免疫反应；宿主-病原体相互作用中的信号事件；各种免疫机制在抵抗传染病中的作用，包括由寄生虫、细菌和逆转录病毒引起的疾病，如艾滋病毒和小鼠艾滋病(女佣)病毒；免疫疗法和疫苗设计。这些领域是利用现代遗传学、免疫学、生化和分子生物学技术进行研究的。我们拥有一流的设施，包括1992年建成的博尔韦尔研究大楼的新实验室。这项提议还受益于现有强大的研究生课程，这些课程有助于获得博士学位。分子发病机制的培训跨越六个系，包括两个研究生项目-生理学和分子和细胞生物学-后者包括大多数参与的教职员工和学生。与该组织一致的是，达特茅斯大学分子发病机制的研究生培训是一种跨学科的方法，由高度互动的环境培养，在这种环境中，学员定期在各种论坛上接触到从临床到基础科学研究的不同教师专业领域，包括一些高级课程、每周研讨会系列和期刊俱乐部，以及务虚会。通过这些方式，我们的受训人员从积极的教员参与和科学交流中受益，从而最大限度地沟通他们的工作、项目教员的工作以及国际上各个跨学科领域的进步。