Host-Microbe Interactions

描述（由申请人提供）：本申请要求支持继续“宿主-微生物相互作用”博士前培训计划，这是著名的微生物学和分子发病机制计划（M2 P2）在达特茅斯的核心。M2 P2是一个跨学科的项目，包括来自达特茅斯和达特茅斯学院Geisel医学院4个系的研究人员。该培训计划旨在为我们的培训师实验室招募的有才华和高度积极性的学生提供研究和基于实验室的培训。M2 P2对达特茅斯生物医学研究界的贡献是至关重要的，正如2010年对更大的研究生项目进行外部审查的最终报告所反映的那样。评审员评论说，M2 P2教师的主动性和成功是值得注意的，做出了实质性的贡献，特别是在课程开发，学生招聘和机构外展领域，使整个计划受益。M2 P2由20名资金充足的培训师组成（2013年直接成本为1560万美元），他们目前在实验室中共有60名学员。我们要求保持目前每年5名受训人员的支助水平。培训包括分子，微生物，动物，人类和生物信息学系统，这为我们的学员提供了广泛的研究和丰富的机会。特别的优势领域包括细菌、真菌、寄生虫和病毒发病机制的分子遗传学，B细胞活化和与T辅助细胞的相互作用，T细胞活性的调节，粘膜免疫应答，宿主-病原体相互作用中的信号事件，持续感染期间的病毒-宿主相互作用，囊性纤维化，以及在治疗和疫苗设计中的应用。这些领域是追求使用现代遗传学，分子，生物化学，免疫学和生物信息学技术的全方位。这项工作是在一流的设施中进行的，资源安置在舒适的工作环境中的现代空间中。达特茅斯已经并将继续大力投资于其生物医学科学基础设施，在本培训计划的上一个资助期内完成了1.95亿美元的新建筑和3600万美元的翻新工程。2013年又开始了1.15亿美元的新建设。在这个程序中训练的学生是从分子和细胞生物学（MCB）多学科研究生课程，这是在达特茅斯最大的研究生课程选择。学生们在这个高度互动的环境中成长，所有学员都参加了一个核心课程。 在研究培训领域，有几门道德操守课程、几门高级课程和职业发展讲习班。此外，他们还参加每周的研讨会系列和期刊俱乐部，并在联合实验室会议和务虚会上展示他们的工作，以及年度MCB范围内的研究进展（RIP）报告。我们的学员特别支持的T32还提供了一系列额外的丰富活动中描述的研究培训计划计划第2.3E节。

DESCRIPTION (provided by applicant): This application requests support to continue the "Host-Microbe Interactions" predoctoral training program that is the centerpiece of the acclaimed Microbiology and Molecular Pathogenesis Program (M2P2) at Dartmouth. M2P2 is an interdisciplinary program that includes faculty investigators from 4 departments in the Geisel School of Medicine at Dartmouth and Dartmouth College. The training program seeks to provide research and curricular-based training to a pool of talented and highly motivated students that have been recruited into our trainers' labs. The contribution of M2P2 to the Dartmouth biomedical research community has been overarching and significant as is reflected in the final report of a 2010 external review of the larger graduate program. The reviewers commented that the initiative and success of the M2P2 faculty is noteworthy, having made substantial contributions, particularly in the areas of curriculum development, student recruitment, and institutional outreach that benefited the entire program. M2P2 consists of 20 well-funded trainers ($15.6M direct costs in 2013) who collectively currently have 60 trainees in their labs. We request to continue the present level of support of 5 trainees per year. Training includes molecular, microbial, animal, human, and bioinformatics systems, which provides our trainees with a wide breadth of research and enrichment opportunities. Particular areas of strength include molecular genetics of bacterial, fungal, parasitic, and viral pathogenesis, B cell activation and interaction with T helper cells, regulation of T cell activity, mucosal immune responses, signaling events in host-pathogen interactions, viral-host interactions during sustained infection, cystic fibrosis, and applications to therapeutic and vaccine design. These areas are pursued using the full range of modern genetic, molecular, biochemical, immunologic, and bioinformatics techniques. This work is conducted in outstanding state-of-the art facilities with resources housed in modern space in a pleasant working environment. Dartmouth has invested and continues to invest heavily in its biomedical sciences infrastructure with $195M of new construction and $36M of renovations completed during the previous funding period of this training program. An additional $115M of new construction began in 2013. Students to be trained in this program are selected from the Molecular and Cellular Biology (MCB) multidisciplinary graduate program, which is the largest graduate program at Dartmouth. Students are nurtured in this highly interactive environment in which all trainees enroll in a core course, several courses in ethics, and several advanced courses and career development workshops pertinent to their area of research training. In addition they participate in weekly seminar series and journal clubs, and present their work at joint lab meetings and retreats, and an annual MCB-wide Research in Progress (RIP) presentation. Our trainees supported specifically by the T32 are also provided with a series of additional enrichment activities described in Research Training Program Plan section 2.3E.