Cancer Biology Training Program

癌症生物学培训计划

• 批准号: 7116273
• 负责人: A. ANGIE RIZZINO
• 金额: $ 33.48万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-22 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7116273
• 关键词: Cancer; Biology; Training; Program

DESCRIPTION (provided by applicant): The Eppley Institute is an academic unit of the University of Nebraska Medical Center (UNMC) with its sole focus on basic cancer research. It is a major component of the NCI-designated UNMC Eppley Cancer Center. UNMC has one of two NCI-designated Cancer Centers in a 6 state region of the heartland and has more than 125 faculty members involved in laboratory and clinical research. As such, the Eppley Institute and the Cancer Research Training Program (CRTP) play an important regional role in training future basic and clinical scientists. We recruit from a national pool of predoctoral and postdoctoral fellows. The NCI Training Grant supports a key part of the CRTP, which currently has 26 predoctoral and 42 postdoctoral fellows in training. The CRTP faculty have a wide variety of expertise in areas important for a broad-based cancer research training program, including biochemistry, cellular and structural biology, drug delivery, genetics, immunology, organic and medicinal chemistry, pathology pharmaceutics and pharmacodynamics, pharmacology, and clinical oncology. The Eppley Institute's CRTP does not grant a doctoral degree, and all entering graduate students have a chance to rotate with CRTP faculty before they pick a thesis advisor in one of the participating departments: Biochemistry and Molecular Biology, Pathology and Microbiology, Pharmaceutical Sciences, and Pharmacology. A number of our trainees are directly involved in translational research activities, e.g., gene-targeted therapy for leukemia, role of catechol estrogens in human breast cancer, radioimmunoconjugate therapy and tumor vaccine development, development of tumor markers for gynecologic cancer. The goal of the training grant is to provide each doctoral student and postdoctoral fellow with the knowledge base, laboratory skills, and problem solving abilities to become independent, innovative cancer investigators. The specific aims of the CRTP are to provide pre- and postdoctoral trainees with: (1) knowledge of the mechanisms of carcinogenesis, the epidemiology of human cancer, and the potential for cancer prevention; (2) an in-depth background in the areas of basic science (biochemistry and molecular biology, genetics, immunology, pathology, pharmaceutical sciences, pharmacology) that is necessary to study and understand the conversion of normal cells to cancer cells and to design methods of diagnosis and treatment; (3) the ability to apply this information to plan and conduct innovative research on the causes, prevention, diagnosis and treatment of cancer; and (4) an appreciation of the power of interdisciplinary research. To achieve these aims the CRTP must be able to attract highly qualified and motivated graduate students and postdoctoral fellows and provide them with high quality didactic and laboratory experiences.

描述（由申请人提供）：Eppley研究所是内布拉斯加大学医学中心（UNMC）的一个学术单位，其唯一的重点是基础癌症研究。 它是NCI指定的UNMC Eppley癌症中心的主要组成部分。 UNMC在中心地带的6个州地区拥有两个NCI指定的癌症中心之一，并拥有超过125名参与实验室和临床研究的教职员工。 因此，Eppley研究所和癌症研究培训计划（CRTP）在培训未来的基础和临床科学家方面发挥着重要的区域作用。 我们从全国博士前和博士后研究员库中招募。 NCI培训补助金支持CRTP的一个关键部分，目前有26名博士前和42名博士后研究员接受培训。 CRTP教师在基础广泛的癌症研究培训计划的重要领域拥有广泛的专业知识，包括生物化学，细胞和结构生物学，药物输送，遗传学，免疫学，有机和药物化学，病理药学和药效学，药理学和临床肿瘤学。 Eppley研究所的CRTP不授予博士学位，所有进入研究生都有机会与CRTP教师轮换，然后在参与部门之一选择论文顾问：生物化学和分子生物学，病理学和微生物学，药物科学和药理学。 我们的许多学员直接参与转化研究活动，例如，白血病的基因靶向治疗，儿茶酚雌激素在人乳腺癌中的作用，放射免疫缀合物治疗和肿瘤疫苗的开发，妇科癌症肿瘤标志物的开发。 培训补助金的目标是为每位博士生和博士后研究员提供知识基础，实验室技能和解决问题的能力，使其成为独立，创新的癌症研究人员。 CRTP的具体目标是为博士前和博士后学员提供：（1）致癌机制，人类癌症流行病学和癌症预防潜力的知识;（2）在基础科学领域的深入背景（生物化学和分子生物学，遗传学，免疫学，病理学，制药科学，药理学），这是必要的研究和了解正常细胞转化为癌细胞，并设计诊断和治疗的方法;（3）有能力应用这些信息来规划和进行有关癌症的病因、预防、诊断和治疗的创新研究;（4）对跨学科研究力量的欣赏。 为了实现这些目标，CRTP必须能够吸引高素质和积极性的研究生和博士后研究员，并为他们提供高质量的教学和实验室经验。