Cancer Biology Training Program

癌症生物学培训计划

• 批准号: 7871448
• 负责人: A. ANGIE RIZZINO
• 金额: $ 31.6万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-22 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7871448
• 关键词: Cancer Biology; Training Programs

DESCRIPTION (provided by applicant): The Eppley Institute is an academic unit of the University of Nebraska Medical Center (UNMC) with its sole focus on cancer research. It is a major component of the NCI-designated UNMC Eppley Cancer Center, which is the only NCI-designated cancer center in a five state region from North Dakota to Texas. As such, the Eppley Institute and the Cancer Biology Training Program (CBTP) play an important regional role in training future basic and clinical scientists. We recruit from a national pool of predoctoral and postdoctoral fellows. The NCI Training Grant supports a key part of the CBTP, which currently has 39 predoctoral and 33 postdoctoral fellows in training. The CBTP faculty has a wide variety of expertise in areas important for a broad-based cancer biology training program, including biochemistry, molecular, cellular and structural biology, drug delivery, genetics, immunology, medicinal chemistry, pathology, pharmaceutics, and clinical oncology. A number of our trainees are directly involved in translational research activities, e.g. role of catechol estrogens in human breast cancer, tumor vaccine development, development of tumor markers for gastrointestinal and oral cavity malignancies, and a Rapid Pancreatic Autopsy Program for harvesting entire organs and selected tissue samples from patients who die of pancreatic adenocarcinoma. The goal of the training grant is to provide each doctoral student and postdoctoral fellow with the knowledge base, laboratory skills, and problem solving abilities to become independent, innovative cancer investigators. The specific aims of the CBTP are to provide pre-and postdoctoral trainees with: (1) knowledge of the mechanisms of carcinogenesis, the pathology of human cancer, and the potential for cancer prevention; (2) an in depth background in the areas of basic science (biochemistry, molecular and cellular biology, genetics, immunology, pharmacology, pharmaceutical sciences) that is necessary to study and understand the conversion of normal cells to cancer cells and to design methods of diagnosis and treatment; (3) the ability to apply this information to plan and conduct innovative research on the causes, prevention, diagnosis, and treatment of cancer; and (4) an appreciation of the power of interdisciplinary research. To achieve these aims, the CBTP must be able to attract highly-qualified and motivated graduate students and postdoctoral fellows and provide them with high quality didactic and laboratory experiences.

描述（由申请人提供）：Eppley研究所是内布拉斯加大学医学中心（UNMC）的一个学术单位，其唯一的重点是癌症研究。它是NCI指定的UNMC Eppley癌症中心的主要组成部分，该中心是从北达科他州到德克萨斯州的五个州地区唯一的NCI指定的癌症中心。因此，Eppley研究所和癌症生物学培训计划（CBTP）在培训未来的基础和临床科学家方面发挥着重要的区域作用。我们从全国博士前和博士后研究员库中招募。NCI培训补助金支持CBTP的一个关键部分，目前有39名博士前和33名博士后研究员接受培训。CBTP教师在基础广泛的癌症生物学培训计划的重要领域拥有广泛的专业知识，包括生物化学，分子，细胞和结构生物学，药物输送，遗传学，免疫学，药物化学，病理学，制药学和临床肿瘤学。我们的一些学员直接参与转化研究活动，例如儿茶酚雌激素在人类乳腺癌中的作用，肿瘤疫苗开发，胃肠道和口腔恶性肿瘤肿瘤标志物的开发，以及快速胰腺尸检计划，用于从死于胰腺癌的患者中获取整个器官和选定的组织样本。培训补助金的目标是为每位博士生和博士后研究员提供知识基础，实验室技能和解决问题的能力，使其成为独立，创新的癌症研究人员。CBTP的具体目标是为博士前和博士后学员提供：（1）致癌机制，人类癌症病理学和癌症预防潜力的知识;（2）在基础科学领域的深入背景（生物化学，分子和细胞生物学，遗传学，免疫学，药理学，药物科学），这是必要的研究和了解正常细胞转化为癌细胞，并设计诊断和治疗的方法;（3）能够应用这些信息来计划和进行有关癌症的原因，预防，诊断和治疗的创新研究;（4）对跨学科研究的力量的赞赏。为了实现这些目标，CBTP必须能够吸引高素质和积极性的研究生和博士后研究员，并为他们提供高质量的教学和实验室经验。