High resolution mapping of the Cochlear nerve using optical stimulation

使用光刺激对耳蜗神经进行高分辨率绘图

• 批准号: 7155562
• 负责人: Mark P Bendett
• 金额: $ 20.19万
• 依托单位: LOCKHEED MARTIN ACULIGHT CORPORATION
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7155562
• 关键词: cochlear implants; cochlear nerve; hearing; heat; lasers; model; tissues

DESCRIPTION (provided by applicant): Neural prosthetic devices are artificial extensions to the body that restore or supplement nervous system function that was lost during disease or injury. Particular success has been realized in the cochlear prostheses development. In contemporary cochlear implants, however, the injected electric current is spread widely along the scala tympani and across turns limiting the number of effective hearing channels. In this Phase 1, we propose an innovative optical cochlear stimulator (OCS) that can increase the number of channels which will ultimately improve the fidelity and research tools of cochlear implants. The first aim is Aculight will develop an optical cochlear stimulator based on previous models and experiments Northwestern University has completed. The methods for the first aim will use Aculight's previous experience with optical nerve stimulators in order to update the electrical and optical designs for use in cochlear implant research. The second aim, Northwestern will test and determine optimal parameters for development of an implantable optical cochlear stimulator. The methods for the second aim will use gerbils to determine the effectiveness and optimize the parameters of the OCS. The outcome of this grant will be a prototype OCS and optimal cochlear implant design parameters that can be implanted in an animal model in the Phase 2 project. This project is intended to benefit those that have lost hearing through disease or injury by developing a tool for research in cochlear implants as well as developing an improved cochlear implant. This research will focus on enhancing the performance of the cochlear implant to allow people to hear speech in a crowded room and even to hear music.

描述(申请人提供)：神经假体装置是对身体的人工延伸，用于恢复或补充在疾病或损伤期间丢失的神经系统功能。在人工耳蜗术的开发方面取得了特别的成功。然而，在当代的人工耳蜗术中，注入的电流沿着鼓阶和轮流广泛传播，限制了有效听力通道的数量。在这一阶段，我们提出了一种创新的光学耳蜗刺激器(OCS)，它可以增加通道数量，最终将提高人工耳蜗术的保真度和研究工具。第一个目标是Aculight将在西北大学之前完成的模型和实验的基础上开发一种光学耳蜗刺激器。第一个目标的方法将利用Aculight以前使用视神经刺激器的经验，以更新用于人工耳蜗研究的电气和光学设计。第二个目标，西北大学将测试和确定开发植入式光学耳蜗刺激器的最佳参数。第二个目标的方法将使用沙土鼠来确定接触网的有效性和优化接触网的参数。这笔赠款的结果将是一个原型OCS和最佳的人工耳蜗设计参数，可以在第二阶段项目的动物模型中植入。该项目旨在通过开发一种研究人工耳蜗的工具，以及开发一种改进的人工耳蜗，使那些因疾病或伤害而失去听力的人受益。这项研究将专注于提高人工耳蜗的性能，使人们能够在拥挤的房间里听到演讲，甚至可以听到音乐。

项目成果

Optical cochlear implants: evaluation of surgical approach and laser parameters in cats.

• DOI: 10.1016/j.heares.2010.06.021
• 发表时间: 2010-10-01
• 期刊: HEARING RESEARCH
• 影响因子: 2.8
• 作者: Rajguru, Suhrud M.;Matic, Agnella Izzo;Robinson, Alan M.;Fishman, Andrew J.;Moreno, Laura E.;Bradley, Allison;Vujanovic, Irena;Breen, Joe;Wells, Jonathon D.;Bendett, Mark;Richter, Claus-Peter
• 通讯作者: Richter, Claus-Peter

Laser stimulation of single auditory nerve fibers.

• DOI: 10.1002/lary.21102
• 发表时间: 2010-10
• 期刊: LARYNGOSCOPE
• 影响因子: 2.6
• 作者: Littlefield, Philip D.;Vujanovic, Irena;Mundi, Jagmeet;Matic, Agnella Izzo;Richter, Claus-Peter
• 通讯作者: Richter, Claus-Peter

Neural stimulation with optical radiation.

• DOI: 10.1002/lpor.200900044
• 发表时间: 2011-01-01
• 期刊: LASER & PHOTONICS REVIEWS
• 影响因子: 11
• 作者: Richter, Claus-Peter;Matic, Agnella Izzo;Wells, Jonathon D.;Jansen, E. Duco;Walsh, Joseph T., Jr.
• 通讯作者: Walsh, Joseph T., Jr.