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Rationale polymer design and selection for microarray transdermal peptide delivery

微阵列透皮肽递送的聚合物设计和选择的基本原理

基本信息

批准号：
2739154
负责人：
金额：
--
依托单位：
University of Nottingham
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2022
资助国家：
英国
起止时间：
2022 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2739154
关键词：
Rationale polymer design selection microarray

项目摘要

Microneedle devices are an attractive route towards painless injection of therapeutics. This administration route is attractive for the delivery of biologics such as peptide-based drugs as the microneedle can act as a stabilising environment for biologics and control their release. One route towards drug release from microneedles is through the disintegration of the material from which the needles are made after application of the microneedle patch. For reproducible drug delivery performance, both the material choice used for the microneedle matrix and the microneedle fabrication process play a critical role. The chemical composition of the microneedles has significant effect on both release rate and, potentially, on batch-to-batch consistency of release. The interplay between these parameters (material composition, processing characteristics) and the performance of peptide delivery through microneedles (peptide stability, amount of peptide loaded, peptide release profile) is not sufficiently understood to enable rational device microneedle design. In this project, we aim to systematically test different polymers for the microneedle device fabrication to establish a correlation between polymer properties, microneedle fabrication process parameters and the performance for peptide-based drug delivery. We will prepare microneedle devices from polymers with varying composition and length to modulate their chemical and mechanical properties and investigate how these properties affect physicochemical and drug release properties of microneedles. The ambition of the work is to ultimately lead towards a predictive tool that enables dialling in a specific microneedle property that is then linked to a suggested polymer composition that will provide the desired microneedle performance.

针式装置是实现治疗剂无痛注射的有吸引力的途径。这种给药途径对于递送生物制剂如基于肽的药物是有吸引力的，因为微针可以充当生物制剂的稳定环境并控制其释放。从微针释放药物的一种途径是在应用微针贴片后分解制成针的材料。对于可再现的药物递送性能，用于微针基质的材料选择和微针制造工艺都起着关键作用。微针的化学组成对释放速率和潜在的批间释放一致性具有显著影响。这些参数（材料组成、加工特性）与通过微针递送肽的性能（肽稳定性、装载的肽量、肽释放曲线）之间的相互作用尚未充分理解，无法实现合理的装置微针设计。在这个项目中，我们的目标是系统地测试用于微针装置制造的不同聚合物，以建立聚合物性质、微针制造工艺参数和基于肽的药物递送性能之间的相关性。我们将从具有不同组成和长度的聚合物制备微针装置，以调节其化学和机械性能，并研究这些性能如何影响微针的物理化学和药物释放性能。这项工作的目标是最终导致一种预测工具，该工具能够调节特定的微针性能，然后将其与建议的聚合物组合物联系起来，从而提供所需的微针性能。