Behavioral Activation Therapy for Adolescents

青少年行为激活疗法

• 批准号: 7080575
• 负责人: ELIZABETH MCCAULEY
• 金额: $ 15.41万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7080575
• 关键词: adolescence (12-20); behavior modification; behavior therapy; behavioral /social science research tag; child behavior; child mental health service; child psychology; clinical depression; clinical research; clinical trials; depression; developmental psychology; human subject; human therapy evaluation; interview; parent offspring interaction; questionnaires; satisfaction; therapy design /development

DESCRIPTION (provided by applicant): Twenty percent of adolescents will have at least one episode of clinical depression by age 18, and 65% will experience transient or less severe depressive symptoms. Depression compromises the process of adolescent development by interfering with academic, occupational, and social functioning, and increasing risk for substance use and suicide. Although Initial research provides some support for both pharmacological and psychosocial interventions for depressed youth, many teens do not respond to these interventions, and others experience a relapse of symptoms within one year. Furthermore, recent concerns about antidepressant medications increasing suicide risk have raised additional concerns about use of pharmacotherapy with adolescents. As such, the importance of developing innovative treatment options for depressed adolescents is critical. Cognitive Behavioral Therapy (CBT) has been demonstrated to be effective in the treatment of depressed adults, with more modest efficacy data when used with children and adolescents. Interestingly, recent data from the adult literature suggests the positive outcomes of CBT can be achieved and surpassed by interventions that are purely behavioral in nature. As behavioral interventions may be easier to implement with many adolescents innovative treatments with such a focus may provide a better developmental fit for depressed adolescents. The present project proposes to develop a manualized Behavioral Activation (BA) Therapy for depressed adolescents, test its adaptability, acceptability, and feasibility in an open clinical trial with 12 adolescents (aged 12-17), and following further treatment refinement, test its efficacy in a randomized controlled trial of 50 adolescents (aged 12-17), in which 25 will be randomized to BA Therapy and 25 will receive "Treatment as Usual (TAU)." In this randomized controlled trial, depressed adolescents will receive 12-weeks of BA Therapy or TAU. Psychiatric and psychosocial functioning will be assessed at the beginning, middle, and end of treatment. A naturalistic follow-up will be conducted 4 and 9 months post-treatment. Assuming that BA will outperform "usual" approaches to therapy with depressed youth, the data will provide the basis for the development of a larger randomized controlled trial comparing the efficacy of BA against other widely studied approaches to the treatment of depression in youth, namely pharmacotherapy in the form of Selective Serotonin Reuptake Inhibitors (SSRIs), and CBT.

描述（由申请人提供）：到18岁时，有20％的青少年将至少有一次临床抑郁症，而65％的青少年会经历短暂的或更严重的抑郁症状。抑郁症通过干扰学术，职业和社会功能以及增加药物使用和自杀的风险来损害青少年发展的过程。尽管最初的研究为抑郁症青年的药理和社会心理干预提供了一些支持，但许多青少年对这些干预措施没有反应，而其他青少年则在一年内经历了症状的复发。此外，最近对增加自杀风险的抗抑郁药的担忧引起了人们对使用青少年使用药物治疗的其他问题。因此，为沮丧的青少年开发创新治疗方案的重要性至关重要。认知行为疗法（CBT）已被证明可以有效地治疗抑郁症的成年人，当与儿童和青少年一起使用时，具有更适度的功效数据。有趣的是，成人文献的最新数据表明，通过纯粹是行为的干预措施，可以实现和超越CBT的积极结果。由于行为干预措施可能更容易与许多青少年以这种重点为重点的创新治疗方法实施，这可能会为沮丧的青少年提供更好的发展。 The present project proposes to develop a manualized Behavioral Activation (BA) Therapy for depressed adolescents, test its adaptability, acceptability, and feasibility in an open clinical trial with 12 adolescents (aged 12-17), and following further treatment refinement, test its efficacy in a randomized controlled trial of 50 adolescents (aged 12-17), in which 25 will be randomized to BA Therapy and 25 will receive "Treatment as Usual （tau）。”在这项随机对照试验中，抑郁症的青少年将接受12周的BA治疗或TAU。将在开始，中间和结尾评估心理和社会心理功能。治疗后4个月和9个月将进行自然主义的随访。假设BA与青少年的抑郁症对治疗的治疗方法胜过，则数据将为开发更大的随机对照试验的发展提供基础，将BA的功效与其他广泛研究的青年抑郁症治疗的方法进行了比较，即以选择性的血清素抑制剂抑制剂（SSRIS）（SSRIS）和CBT的形式。