BUILDING A TOOTH: The Chicago Blueprint for Dental Regeneration

描述（由申请人提供）：尽管在生物激发的牙齿再生方面已经取得了切实的进展，最终目标似乎比以往任何时候都更触手可及，但仍需要做出重大努力，以实现基础研究成果对牙齿再生医学的治疗应用，并将牙齿再生的梦想变为现实。为了应对牙齿器官再生的新挑战和机遇，我们招募了一个芝加哥的研究团队，与国内和国际合作者一起为U54专业中心制定了一个概念发展计划，致力于牙齿组织再生。在一起，我们的团队准备为牙齿组织再生的挑战提供答案。为了解决个别研究问题，我们将当地专家与芝加哥以外的合作伙伴配对，并将牙科组织生物学的领导者与整个努力成功所必需的基础学科的尖端科学家配对。在规划阶段，我们着重于四个主要主题。主题1。制定全牙器官再生的实施策略。主题2。设计方法和生物启发的概念来设计牙釉质。主题3。设想牙本质再生的途径。主题4。设计牙周再生的新概念。我们认为，该计划的实现将为临床成功的口腔组织再生提供蓝图，为医学器官再生提供进一步的工具和见解，并为预防口腔疾病和口腔组织再生提供额外的策略。

DESCRIPTION (provided by applicant): Even though tangible progress toward biologically inspired tooth regeneration has been made and the ultimate goal appears more within reach than ever, significant efforts may still be required to accomplish therapeutic applicability of basic research findings toward dental regenerative medicine and to turn the dream of dental regeneration into practical reality. In order to respond to the emerging challenges and opportunities in tooth organ regeneration, we have recruited a Chicago- based research team together with national and international collaborators to generate a concept development plan for a U54 Specialized Center dedicated to the purpose of dental tissue regeneration. Together, our team is prepared to provide answers to the challenges of dental tissue regeneration. In order to address individual research questions, we have paired local experts with partners outside of Chicago, and leaders in dental tissue biology with cutting edge scientists in the fundamental subjects necessary for the success of the entire endeavor. For the planning phase, we have focused on four principal themes. Theme 1. To develop strategies for the implementation of entire tooth organ regeneration. Theme 2. To design methods and bio-inspired concepts to engineer tooth enamel. Theme 3. To conceive approaches toward dentin regeneration. Theme 4. To devise novel concepts toward periodontal regeneration. We propose that the realization of our plan will provide the blueprint for clinically successful dental tissue regeneration, generate further tools and insights toward medical organ regeneration, and yield in additional strategies for the prevention of oral disease and regeneration of oral tissues.