Dovetailing MRI and in-vivo physiology

MRI 与体内生理学相吻合

• 批准号: 2741066
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2741066
• 关键词: Dovetailing; MRI; vivo; physiology

The mechanisms behind muscle repair and recovery following eccentric and concentric loading are not fully understood, with the primary investigative tool being the muscle biopsy. However, this is an invasive procedure, and is limited by the histology of the tissue. By using Chemical Exchange Saturation Transfer (CEST) and sodium MR techniques, and applying them to muscle damage models, it is hoped that a non invasive method of studying muscle physiology can be developed.

偏心和同心负荷后肌肉修复和恢复的机制尚未完全了解，主要的研究工具是肌肉活检。然而，这是一种侵入性手术，并且受到组织的组织学的限制。利用化学交换饱和转移（CEST）和钠MR技术，并将其应用于肌肉损伤模型，希望能发展一种无创的研究肌肉生理的方法。