Dopamine's role in pain sensivity & placebo analgesia

描述(申请人提供)：这里提出的研究涉及中枢多巴胺系统在内源性疼痛调制中的作用，因为它与对有害刺激的敏感性有关，以及在给予安慰剂止痛剂后利用抗伤害感受资源的能力。基于来自动物文献的大量数据和来自临床样本和健康人类志愿者的聚合证据，我们认为初级多巴胺能奖赏通路神经成分中的D2样多巴胺受体密度与这些调节能力存在差异相关。也有人提出，关于接受据称有效的止痛药的程度和可能性的信念将影响安慰剂反应和D2多巴胺受体密度之间的关系。这项拟议的研究将测试基线疼痛敏感性和接受据称有效治疗的可能性高或低时的安慰剂止痛药是否与纹状体和纹状体外脑区的D2/D3多巴胺受体的可用性有关，这是用[18F]FolyPride PET测量的。

DESCRIPTION (provided by applicant): The research presented here addresses the role of the central dopamine system in endogenous pain modulation as it pertains to sensitivity to noxious stimuli, and the capacity to engage antinociceptive resources following administration of placebo analgesic. Based on substantial data from the animal literature and converging evidence from both clinical samples and healthy human volunteers, it is proposed that D2- like dopamine receptor density in neural components of the primary dopaminergic reward pathway is differentially associated with these modulatory capacities. It is also proposed that beliefs regarding magnitude and probability of receiving a purportedly active analgesic will affect the relationship between placebo response and D2 dopamine receptor density. The proposed study will test whether baseline pain sensitivity and placebo analgesia when there is a high or low probability of receiving a purportedly active treatment are associated with D2/D3 dopamine receptor availability in striatal and extrastriatal brain regions as measured with [18F]fallypride PET.