Behavioral and Clinical Research in a Long-Running Longitudinal Survey

描述（由申请人提供）：本申请涉及广泛的挑战领域（04）临床研究和特定的挑战主题04- DA-102：“纵向数据的新视角”。这一努力不仅将通过大幅扩展已经全面的数据资源的广度来启动全新的研究路线，而且还将通过收集数据来对生物医学和行为科学产生重大影响，这些数据将整合生物医学领域的前沿工作和卓越的数据资源，用于代际纵向研究母亲及其子女的行为。NLSY 79一直在收集大量的健康信息，包括在NIDA的大力支持下收集大量关于毒品和其他物质使用的数据。国家排雷中心还支持广泛收集女性答卷人子女的社会、情感和认知发展情况。这一应用程序将允许两个非常重要的改进-它将防止老年母亲所生子女在青春期的关键数据丢失，包括有关物质使用和其他非规范行为的关键数据，以及性行为，同伴关系，学校进步，早期劳动力市场行为，以及重要的健康结果，如BMI和其他健康相关状况。第二个重要的改进将是准备将生物标志物纳入这个广泛使用的代际纵向数据资源。与NIH或NSF支持的大多数调查相比，NLS面临着一个相当不同的监管环境，准备收集生物标志物的过程将非常小心，不仅要确保科学正确，而且要谈判监管障碍。我们将广泛咨询其他收集生物标志物的项目，以确保科学界获得最佳价值。NLSY 79的独特历史和组成提供了一个非凡的机会，如果获得资助，该项目将在未来几十年内支付红利，并使NIH的多个研究所受益，包括NIDA，NICHD，NIA等。公共卫生相关性声明：为了了解健康结果，我们一方面需要了解社会经济，人口和环境因素的作用，另一方面需要了解临床因素。该项目将支持NLSY 79这两个研究项目的统一-这是研究界最常用的代际纵向调查之一。

DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (04) Clinical Research, and the specific Challenge Topic, 04- DA-102: "A New Look at Longitudinal Data". This effort will not only jumpstart entirely new lines of research by substantially expanding the breadth of an already comprehensive data resource, but will also have significant influence on both biomedical and behavioral science by collecting data that will integrate frontier work in biomedical areas with the preeminent data resource for intergenerational longitudinal research into the behaviors of mothers and their children. The NLSY79 has always collected substantial amounts of health information including, with very substantial support by NIDA, a great deal of data on drug and other substance use. NICHD has also supported an extensive collection on the social, emotional and cognitive development of the children of the female respondents. This application would permit two very important improvements - it will prevent the loss of critical data in the adolescent years of children born to older mothers, including crucial data on substance use and other non-normative behavior, as well as sexual behavior, peer relationships, progress in school, early labor market behavior, and important health outcomes such as BMI and other health-related conditions. The second important improvement would be to prepare the way to incorporate biomarkers into this heavily used, intergenerational longitudinal data resource. The NLS faces a rather different regulatory environment than most surveys supported by NIH or NSF and the process of preparing for collecting biomarkers will take great care not only to get the science right, but in negotiating the regulatory hurdles. We will be consulting widely with other projects that are collecting biomarkers to insure the scientific community gets the best value for its money. The unique history and composition of the NLSY79 presents a remarkable opportunity and, if funded, this project will pay dividends for decades to come and benefit multiple institutes at NIH including NIDA, NICHD, NIA among others. Public Health Relevance Statement: To understand health outcomes, we need to understand the role of socio-economic, demographic and environmental factors on one hand, and clinical factors on the other. This project will support the unification of these two research programs for the NLSY79 - one of the most heavily used intergenerational longitudinal surveys available to the research community.