Behavioral and Clinical Research in a Long-Running Longitudinal Survey

描述(由申请人提供)：本申请涉及广泛的挑战领域(04)临床研究，以及具体的挑战主题04-DA-102：“纵向数据的新视角”。这一努力不仅将极大地扩展已经全面的数据资源的广度，从而启动全新的研究路线，而且还将通过收集数据对生物医学和行为科学产生重大影响，这些数据将把生物医学领域的前沿工作与卓越的数据资源相结合，用于对母亲及其子女的行为进行跨代纵向研究。NLSY79总是收集大量的健康信息，包括在NIDA的大力支持下，关于药物和其他物质使用的大量数据。NICHD还支持广泛收集女性受访者子女的社会、情感和认知发展情况。这项应用将允许两个非常重要的改进--它将防止大龄母亲所生孩子在青春期的关键数据丢失，包括关于药物使用和其他非规范性行为的关键数据，以及性行为、同伴关系、学校进步、早期劳动力市场行为以及BMI和其他与健康相关的疾病等重要健康结果的关键数据。第二个重要的改进将是准备将生物标志物纳入这一大量使用的、代际纵向数据资源中。与NIH或NSF支持的大多数调查相比，NLS面临的监管环境截然不同，收集生物标记物的准备过程将非常小心，不仅要让科学正确，而且要谈判监管障碍。我们将与其他正在收集生物标志物的项目进行广泛的咨询，以确保科学界获得最大的资金价值。NLSY79独特的历史和组成提供了一个绝佳的机会，如果获得资金，该项目将在未来几十年内带来红利，并使NIH的多个研究所受益，包括NIDA、NICHD、NIA等。公共卫生相关声明：要了解健康结果，我们一方面需要了解社会经济、人口和环境因素以及临床因素的作用。该项目将支持NLSY79的这两个研究项目的统一，NLSY79是研究界可用的最常用的代际纵向调查之一。

DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (04) Clinical Research, and the specific Challenge Topic, 04- DA-102: "A New Look at Longitudinal Data". This effort will not only jumpstart entirely new lines of research by substantially expanding the breadth of an already comprehensive data resource, but will also have significant influence on both biomedical and behavioral science by collecting data that will integrate frontier work in biomedical areas with the preeminent data resource for intergenerational longitudinal research into the behaviors of mothers and their children. The NLSY79 has always collected substantial amounts of health information including, with very substantial support by NIDA, a great deal of data on drug and other substance use. NICHD has also supported an extensive collection on the social, emotional and cognitive development of the children of the female respondents. This application would permit two very important improvements - it will prevent the loss of critical data in the adolescent years of children born to older mothers, including crucial data on substance use and other non-normative behavior, as well as sexual behavior, peer relationships, progress in school, early labor market behavior, and important health outcomes such as BMI and other health-related conditions. The second important improvement would be to prepare the way to incorporate biomarkers into this heavily used, intergenerational longitudinal data resource. The NLS faces a rather different regulatory environment than most surveys supported by NIH or NSF and the process of preparing for collecting biomarkers will take great care not only to get the science right, but in negotiating the regulatory hurdles. We will be consulting widely with other projects that are collecting biomarkers to insure the scientific community gets the best value for its money. The unique history and composition of the NLSY79 presents a remarkable opportunity and, if funded, this project will pay dividends for decades to come and benefit multiple institutes at NIH including NIDA, NICHD, NIA among others. Public Health Relevance Statement: To understand health outcomes, we need to understand the role of socio-economic, demographic and environmental factors on one hand, and clinical factors on the other. This project will support the unification of these two research programs for the NLSY79 - one of the most heavily used intergenerational longitudinal surveys available to the research community.