Behavioral and Clinical Research in a Long-Running Longitudinal Survey

描述（由申请人提供）：本申请涉及广泛的挑战领域（04）临床研究，以及具体的挑战主题，04- DA-102：“纵向数据的新视角”。这一努力不仅将通过大大扩展已经全面的数据资源的广度而启动全新的研究路线，而且还将通过收集数据将生物医学领域的前沿工作与母亲及其子女行为代际纵向研究的卓越数据资源结合起来，从而对生物医学和行为科学产生重大影响。NLSY79一直在收集大量的健康信息，包括在NIDA的大力支持下，大量关于药物和其他物质使用的数据。儿童发展中心还支持广泛收集关于女性答复者子女的社会、情感和认知发展的资料。这一应用程序将带来两项非常重要的改进——它将防止大龄母亲所生儿童在青少年时期的关键数据丢失，包括关于物质使用和其他非规范行为的关键数据，以及性行为、同伴关系、学业进步、早期劳动力市场行为和重要的健康结果（如BMI和其他健康相关状况）的关键数据。第二个重要的改进是准备将生物标志物纳入这种大量使用的代际纵向数据资源。与NIH或NSF支持的大多数调查相比，NLS面临着一个截然不同的监管环境，收集生物标志物的准备过程不仅要确保科学正确，而且要在监管障碍方面进行谈判。我们将与其他正在收集生物标记物的项目进行广泛磋商，以确保科学界的资金得到最大的回报。NLSY79的独特历史和组成提供了一个非凡的机会，如果得到资助，该项目将在未来几十年带来红利，并使NIH的多个研究所受益，包括NIDA， NICHD， NIA等。公共卫生相关性声明：为了了解健康结果，我们需要了解社会经济、人口和环境因素的作用，以及临床因素的作用。该项目将支持NLSY79这两个研究项目的统一，NLSY79是研究界使用最广泛的代际纵向调查之一。

DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (04) Clinical Research, and the specific Challenge Topic, 04- DA-102: "A New Look at Longitudinal Data". This effort will not only jumpstart entirely new lines of research by substantially expanding the breadth of an already comprehensive data resource, but will also have significant influence on both biomedical and behavioral science by collecting data that will integrate frontier work in biomedical areas with the preeminent data resource for intergenerational longitudinal research into the behaviors of mothers and their children. The NLSY79 has always collected substantial amounts of health information including, with very substantial support by NIDA, a great deal of data on drug and other substance use. NICHD has also supported an extensive collection on the social, emotional and cognitive development of the children of the female respondents. This application would permit two very important improvements - it will prevent the loss of critical data in the adolescent years of children born to older mothers, including crucial data on substance use and other non-normative behavior, as well as sexual behavior, peer relationships, progress in school, early labor market behavior, and important health outcomes such as BMI and other health-related conditions. The second important improvement would be to prepare the way to incorporate biomarkers into this heavily used, intergenerational longitudinal data resource. The NLS faces a rather different regulatory environment than most surveys supported by NIH or NSF and the process of preparing for collecting biomarkers will take great care not only to get the science right, but in negotiating the regulatory hurdles. We will be consulting widely with other projects that are collecting biomarkers to insure the scientific community gets the best value for its money. The unique history and composition of the NLSY79 presents a remarkable opportunity and, if funded, this project will pay dividends for decades to come and benefit multiple institutes at NIH including NIDA, NICHD, NIA among others. Public Health Relevance Statement: To understand health outcomes, we need to understand the role of socio-economic, demographic and environmental factors on one hand, and clinical factors on the other. This project will support the unification of these two research programs for the NLSY79 - one of the most heavily used intergenerational longitudinal surveys available to the research community.