Renal Inflammation: Mechanisms and Consequences

描述（由申请人提供） 奥布莱恩肾脏炎症中心的使命是促进我们对肾脏疾病炎症发生、维持和消退机制的理解。肾脏炎症被认为在急性肾衰竭、肾小球肾炎、糖尿病肾病、高血压和进行性肾病的发病机制中具有关键作用。在这个中心的应用程序中，我们汇集了在炎症的不同方面的专业知识的科学家，以提供一个在肾脏炎症所涉及的机制的凝聚力和全面的调查。多学科的方法将集中在促炎和抗炎机制，重点是没有受到太多关注的分子（例如，尿酸）或最近才被鉴定为在炎症中起作用。后者包括新趋化因子（CXCL 16）、新粘附分子（JAM家族）、最近发现的Slit/Robo家族、信号分子Smad 7和斯钙素。一个病理学核心，重点是这些分子在人类疾病中的作用，将提供临床相关性，并将是一个机制，为潜在的未来临床研究应用的基础科学观察。该中心还将培训奖学金候选人从事学术肾脏病学的职业（与目前正在审查的T-32培训补助金相结合），帮助启动初级研究人员的职业生涯（通过DR/P&F计划），并提供与贝勒其他中心的强有力的互动，这些中心也专注于炎症反应（如炎症生物学中心）。综合的，多学科的，协同的和全面的方法来研究肾脏炎症应该提供一个更好地了解肾脏疾病的发病机制，并可能提供新的治疗见解。

DESCRIPTION (provided by applicant) The O'Brien Center for Renal Inflammation has the mission of furthering our understanding of the mechanisms involved in the initiation, maintenance, and resolution of inflammation in renal disease. Renal inflammation is recognized to have a critical role in the pathogenesis of acute renal failure, glomerulonephritis, diabetic nephropathy, hypertension, and progressive renal disease. In this Center application, we have brought together scientists with expertise in different aspects of inflammation to provide a cohesive and comprehensive investigation of the mechanisms involved in renal inflammation. The multidisciplinary approach will focus on both proinflammatory and anti-inflammatory mechanisms with an emphasis on molecules that have either not received much attention (e.g., uric acid) or that have only recently been identified as having a role in inflammation. The latter includes new chemokines (CXCL16), new adhesion molecules (JAM family), the recently discovered Slit/Robo family, the signaling molecule Smad7, and stanniocalcin. A pathology core that focuses on the role of these molecules in human disease will provide clinical relevance and will be a mechanism for translating basic science observations for potential future clinical research application. The Center will also train fellowship candidates for a career in academic nephrology (in concert with a T-32 training grant which is currently under review), help initiate the careers of junior investigators (via the DR/P&F program), and provide a strong interaction with the other Centers at Baylor that also focus on the inflammatory response (such as the Biology of Inflammation Center). The integrated, multidisciplinary, synergistic and comprehensive approach to study renal inflammation should provide a better understanding of the pathogenesis of renal disease and may provide new therapeutic insights.