Research Training in Renal Diseases

肾脏疾病研究培训

• 批准号: 7901050
• 负责人: WILLIAM Evans MITCH
• 金额: $ 16.61万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7901050
• 关键词: Kidney Diseases; Research Training

DESCRIPTION (provided by applicant): Training young scientists in nephrology is especially needed because of the prevalence of CKD with its devastating complications (e.g., cardiovascular disease (CVD), inflammation, malnutrition, etc.). The nephrologist's special knowledge about kidney function and CKD complications can lead to substantial advances in preventing and treating these complications (e.g, how uremia influences vascular complications, protein metabolism, etc.). Our goal is to provide superb scientific training so bright, young physicians will develop the skills needed to become competitive investigators. To accomplish this, we have recruited 3 NEH-funded mentors to provide training and have detailed didactic opportunities for those interested in clinical investigations. We continue to take advantage of the rich scientific environment of Baylor. Our overall rationale is that interdisciplinary research training based on state-of-the-art techniques in an environment emphasizing basic and translational research will stimulate fellows to investigate how and why kidney disease and its complications develop. Our interdisciplinary Training Program includes 2 (preferably 3 years) of research training working directly with preceptors who are established basic or clinical investigators and have a record of training scientists and NIH funding plus a history of interactions with Nephrology faculty and each other. Research areas include mechanisms causing CVD (lipid metabolism, diabetic complications, arteriosclerosis, the cell biology of heart fibrosis and neointima development in vein grafts). The contributions of cytokine and signaling pathways to inflammation, kidney damage and mechanisms of muscle wasting. Each year we plan for 3 MD/MD-PhD trainees, who will train for a minimum of 2 years with mentors who have extensive experience in basic or clinical sciences. Training will include a strong didactic program to ensure a background sufficient to understand rigorous experimental design and dedication to scientific principles, biostatistics and ethics. The interdisciplinary plan integrates different scientific disciplines and takes advantage of the intellectual opportunities and core facilities of Baylor. Relevance: millions of Americans have kidney disease and more are at risk of developing kidney disease and its complications because of the growing prevalence of diabetes. Bright young nephrologist-scientists trained in research must be trained so they can advance the treatment of patients with CKD and its complications.

描述（由申请人提供）： 尤其需要培训年轻科学家肾脏科学的肾脏科学，因为CKD的流行率具有毁灭性的并发症（例如心血管疾病（CVD），炎症，营养不良等）。肾脏科医生关于肾功能和CKD并发症的特殊知识可能会导致预防和治疗这些并发症的重大进展（例如，尿emia如何影响血管并发症，蛋白质代谢等）。我们的目标是提供出色的科学培训，以便聪明，年轻的医生将发展成为竞争性研究人员所需的技能。为此，我们已经招募了3位NEH资助的导师，以提供培训，并为那些对临床研究感兴趣的人提供了详细的教学机会。我们继续利用贝勒的丰富科学环境。我们的总体理由是，在强调基本和转化研究的环境中，基于最新技术的跨学科研究培训将刺激研究员，以调查肾脏疾病及其并发症的发展以及为什么发展。我们的跨学科培训计划包括直接与建立基础或临床研究人员的受体直接合作，有培训科学家和NIH资金的记录，以及与肾脏学教师互动的历史，彼此相互作用的历史。研究领域包括引起CVD的机制（脂质代谢，糖尿病并发症，动脉粥样硬化，心脏纤维化的细胞生物学和静脉移植物中的新内膜发育）。细胞因子和信号通路对炎症，肾脏损伤和肌肉浪费机制的贡献。每年，我们都计划3名MD/MD-PHD学员，他们将在基础科学或临床科学方面拥有丰富经验的导师至少培训2年。培训将包括一个强大的教学计划，以确保背景足以了解严格的实验设计以及对科学原则，生物统计学和道德规范的奉献精神。跨学科计划整合了不同的科学学科，并利用了贝勒的智力机会和核心设施。相关性：数以百万计的美国人患有肾脏疾病，并且由于糖尿病患病率的增长，有更多的肾脏疾病及其并发症的风险。必须培训接受研究的年轻肾脏科学家科学家，以便他们可以促进CKD患者及其并发症的治疗。