Research Training in Renal Diseases

描述(由申请人提供)： 由于慢性肾脏病及其破坏性并发症(如心血管疾病、炎症、营养不良等)的流行，尤其需要对年轻科学家进行肾脏病方面的培训。肾内科医生对肾功能和CKD并发症的专门知识可以在预防和治疗这些并发症(例如，尿毒症如何影响血管并发症、蛋白质代谢等)方面取得实质性进展。我们的目标是提供一流的科学培训，使年轻的医生能够培养成为有竞争力的研究人员所需的技能。为了实现这一目标，我们招募了3名NEH资助的导师来提供培训，并为那些对临床研究感兴趣的人提供详细的授课机会。我们继续利用贝勒丰富的科学环境。我们的总体理念是，在强调基础研究和转化性研究的环境中，基于最先进技术的跨学科研究培训将刺激研究员调查肾脏疾病及其并发症是如何以及为什么发生的。我们的跨学科培训计划包括2年(最好是3年)的研究培训，直接与导师合作，这些导师是公认的基础或临床研究人员，有培训科学家和NIH资金的记录，以及与肾脏病教员和彼此互动的历史。研究领域包括导致心血管疾病的机制(脂代谢、糖尿病并发症、动脉硬化、心脏纤维化的细胞生物学和静脉移植物的新生内膜形成)。细胞因子和信号通路在炎症、肾脏损伤和肌肉萎缩机制中的作用。我们每年计划招收3名MD/MD-PhD实习生，他们将在具有丰富基础或临床科学经验的导师的指导下接受至少2年的培训。培训将包括一个强有力的教学计划，以确保有足够的背景知识来理解严格的实验设计，并致力于科学原理、生物统计学和伦理学。跨学科计划整合了不同的科学学科，并利用了贝勒的智力机会和核心设施。相关性：数以百万计的美国人患有肾脏疾病，由于糖尿病的日益流行，更多的人面临发展为肾脏疾病及其并发症的风险。年轻聪明的肾病学家--受过研究训练的科学家必须经过培训，这样他们才能推进慢性肾脏病及其并发症的治疗。

DESCRIPTION (provided by applicant): Training young scientists in nephrology is especially needed because of the prevalence of CKD with its devastating complications (e.g., cardiovascular disease (CVD), inflammation, malnutrition, etc.). The nephrologist's special knowledge about kidney function and CKD complications can lead to substantial advances in preventing and treating these complications (e.g, how uremia influences vascular complications, protein metabolism, etc.). Our goal is to provide superb scientific training so bright, young physicians will develop the skills needed to become competitive investigators. To accomplish this, we have recruited 3 NEH-funded mentors to provide training and have detailed didactic opportunities for those interested in clinical investigations. We continue to take advantage of the rich scientific environment of Baylor. Our overall rationale is that interdisciplinary research training based on state-of-the-art techniques in an environment emphasizing basic and translational research will stimulate fellows to investigate how and why kidney disease and its complications develop. Our interdisciplinary Training Program includes 2 (preferably 3 years) of research training working directly with preceptors who are established basic or clinical investigators and have a record of training scientists and NIH funding plus a history of interactions with Nephrology faculty and each other. Research areas include mechanisms causing CVD (lipid metabolism, diabetic complications, arteriosclerosis, the cell biology of heart fibrosis and neointima development in vein grafts). The contributions of cytokine and signaling pathways to inflammation, kidney damage and mechanisms of muscle wasting. Each year we plan for 3 MD/MD-PhD trainees, who will train for a minimum of 2 years with mentors who have extensive experience in basic or clinical sciences. Training will include a strong didactic program to ensure a background sufficient to understand rigorous experimental design and dedication to scientific principles, biostatistics and ethics. The interdisciplinary plan integrates different scientific disciplines and takes advantage of the intellectual opportunities and core facilities of Baylor. Relevance: millions of Americans have kidney disease and more are at risk of developing kidney disease and its complications because of the growing prevalence of diabetes. Bright young nephrologist-scientists trained in research must be trained so they can advance the treatment of patients with CKD and its complications.