PROTEINS IN MATERNAL SERUM ASSOCIATED WITH THE PREECLAMPSIA

描述(由申请人提供)： 夏威夷大学(UH)临床研究卓越中心(CCRE)的续签申请是根据NOT-RR-04-003和RR-99-005提交的。约翰·A·伯恩斯医学院(JABSOM)致力于在人类早期发育方面建立一个卓越的研究中心，该中心将1)进一步增强和加强研究能力，2)指导初级研究人员进行有价值的初步研究，从而成功竞争R系列和P系列拨款，3)吸引其他研究人员来补充早期人类发育的具体研究领域，以及4)有助于减少和消除夏威夷不同种族群体，特别是亚洲人、夏威夷原住民和其他太平洋岛民在人类早期发展方面的健康差距。三个合作伙伴，包括六个JABSOM附属实体(卡皮奥拉尼妇女儿童医学中心、临床研究中心、儿科和妇产科及妇女健康科、生物发生研究所和分子内分泌科)、两个社区组织(地区健康教育中心和怀马纳罗健康中心)和犹他大学妇产科，已同意参与建立一个专题CCRE中心，题为“太平洋人类早期发育研究中心”(PRCEHD或中心)。该中心将侧重于指导初级研究人员，并制定创新的方案，旨在加强JABSOM的研究能力，以减少和消除人类早期发育方面的差距。反过来，通过在翻译研究方面的新合作，该中心将加强JABSOM作为GCRC申请人的地位，预计在未来六年内获得GCRC资格。

DESCRIPTION (provided by applicant): This renewal application for the Center of Clinical Research Excellence (CCRE) at the University of Hawaii (UH) is submitted in response to NOT-RR-04-003 and RR-99-005. The John A. Burns School of Medicine (JABSOM) seeks to establish a center of research excellence in early human development that will 1) further augment and strengthen research capacity, 2) mentor junior investigators as they conduct meritorious preliminary research leading to successful competition for R- and P-series grants, 3) attract other investigators to complement the specific research area of early human development, and 4) contribute to reduction and elimination of health disparities in early human development in diverse ethnic groups in Hawaii, particularly Asians, Native Hawaiians and other Pacific Islanders. Three partners, including six JABSOM-affiliated entities (Kapiolani Medical Center for Women and Children, the Clinical Research Center, the Departments of Pediatrics and Obsetrics and Gynecology and Women's Health, the Institute for Biogenesis Research, and the Section on Molecular Endocrinology), two community organizations (The Area Health Education Centers and Waimanalo Health Center), and the University of Utah Department of Obstetrics and Gynecology, have agreed to participate in collaborative efforts to establish a thematic CCRE center entitled the "Pacific Research Center for Early Human Development" (PRCEHD or Center). This Center will focus on mentoring junior investigators and developing innovative protocols designed to enhance research capacity at JABSOM to reduce and eliminate disparities in early human development. In turn, through new collaborations in translational research, the Center will strengthen JABSOM's position as an applicant for GCRC status, which is anticipated within the next six years.