HUMAN DECIDUA AND FETAL MEMBRANES AS A PARACRINE SYSTEM

生殖系统的内分泌学是建立在 内分泌信号和不易被截取的信号 细胞间(旁分泌)和细胞内(自分泌和内分泌) 控制着当地的现象。分娩的控制机制 对妇女的歧视是一种独特的本地现象。最合适的模式 用于研究的是胎儿/母亲的界面，由细胞和 胎儿羊膜、绒毛和母体的细胞外基质 人类胎膜的蜕膜。这些东西很容易拿到，但是 仅在有限的时间点，用于活体观察和 体外实验。因此，在足月获得的正常组织中， 基于人类的自分泌/旁分泌系统已经被定义 松弛素类及其对激活剂--特异性金属蛋白酶的调控 和抑制剂。胶原蛋白分解的控制和一种新的 羊膜-绒毛膜中新的弹性系统现在可以解释胎儿的膜 第一次实现了容纳性和弹性。早产早产 在没有感染的情况下胎儿胎膜破裂 早产是围产期医学中的一个重大问题，可以 现在通过(1)在体内寻找过量的证据来研究 松弛素的产生或松弛素受体的表达 怀孕20-36周的妇女早产。(2)示范 松弛素/松弛素受体增加的关系 在体内和体外表达并增加胶原酶的分解，从而 松弛素链与胎儿早产早破 膜。综合结果将显示，松弛类药物是 与早产儿胎膜早破有关 早产：围产医学在这方面的一个重大问题 今天的国家。

The endocrinology of the reproductive system is based on systemic endocrine signalling and on the less readily intercepted signals between cells (paracrine) and within cells (autocrine and intracrine) which control local phenomena. The mechanism controlling parturition in women is a unique and local phenomenon. The most appropriate model for study, is the fetal/maternal interface, provided by the cells and extracellular matrix of the fetal amnion and chorion and the maternal decidua of the human fetal membranes. These are readily accessible, but only at a limited number of time points, for observation in vivo and experimentation in vitro. Hence, in normal tissues obtained at term, an autocrine/paracrine system has already been defined based on human relaxins and their control of specific metalloproteinases, an activator and inhibitor. The control of collagen breakdown and the finding of a novel elastic system in the amnion-chorion now explains fetal membrane accommodation and elasticity for the first time. Preterm premature rupture of the fetal membranes in the absence of infection resulting in preterm birth is a significant problem in perinatal medicine and can now be studied here by (1) seeking evidence in vivo for the excessive production of relaxins an-or expression of the relaxin receptor in women delivering preterm at 20-36 weeks gestation. (2) demonstrating a relationship between the increased relaxin/relaxin receptor expression and increased collagenolysis in vivo and in vitro, thereby linking relaxins and the preterm premature rupture of the fetal membranes. The combined results will show that the relaxins are involved in the preterm premature rupture of the fetal membranes and preterm birth: a significant problem in perinatal medicine in this country today.