Functional Organization of the Song Motor Control System

Song电机控制系统的功能结构

• 批准号: 7012194
• 负责人: MARC F SCHMIDT
• 金额: $ 26.53万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-03-15 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7012194
• 关键词: animal communication behavior; behavioral /social science research tag; brain interhemispheric activity; cell type; electronic recording system; electrostimulus; neuronal guidance; psychomotor function; sensory feedback; songbirds; stereotaxic techniques; telencephalon; vocalization

DESCRIPTION (provided by applicant): Birdsong is a hierarchically patterned learned motor behavior controlled by a nearly serially connected stream of nuclei. This pathway is bilaterally organized, with anatomically indistinguishable structures in each hemisphere. Little is known regarding the nature, or organization, of song features that are encoded by these structures. In the present proposal, we use a number of complimentary experimental techniques (single- and multi-unit recording, stimulation and lesions) to investigate the organization of song feature encoding in HVc, a key telencephalic song control nucleus. These studies will be performed in singing adult zebra finches (Taeniopygia guttata) under normal and perturbed sensory feedback conditions. In AIM 1, we exploit interhemispheric coordination of song motor activity in HVc to study the relationship between premotor activity and song output. We hypothesize that analysis of neural patterns recorded simultaneously in both hemispheres will provide insight into the hierarchical encoding of song features. We propose that patterns of coincident activity across hemispheres will specify key song timing features such as syllable, and possibly note, onset and offset. Sensory feedback perturbations cause long-term changes in song output of adult songbirds. It is not known how such perturbations affect song premotor neural patterns in HVc. AIM 2 will compare neural activity patterns in HVc before and directly after cutting the tracheosyringeal (ts) nerve, a manipulation that alters both acoustic and proprioceptive feedback. We will use multiunit recording to initially characterize the effect of such perturbations on the HVc population response. We will then use single-unit recordings to identify neuronal cell types that are affected by sensory feedback manipulation. Finally, AIM 3 will investigate how perturbations of HVc network activity, either by microlesions or stimulation, affect the normally stereotyped song output of adult zebra finches. To eliminate the possibility of compensatory activity in the intact contralateral HVc, spatially restricted manipulations will be performed in birds forced to sing with only one song system hemisphere. The proposed studies directly address the spatial and temporal organization of song feature encoding in HVc.

描述（由申请人提供）：鸟鸣是一种分层模式的学习运动行为，由一个几乎串联连接的细胞核流控制。这条通路是双侧组织的，每个半球都有解剖学上无法区分的结构。关于这些结构编码的歌曲特征的性质或组织知之甚少。在本建议中，我们使用了一些免费的实验技术（单和多单位记录，刺激和病变），以调查组织的歌曲特征编码HVC，一个关键的端脑歌曲控制核。这些研究将在正常和扰动的感觉反馈条件下，在唱歌的成年斑胸草雀（Taeniopygia guttata）。 在AIM 1中，我们利用HVc中的歌曲运动活动的半球间协调来研究运动前活动和歌曲输出之间的关系。我们假设，同时记录在两个半球的神经模式的分析将提供深入了解的分层编码的歌曲功能。我们建议，跨半球的重合活动的模式将指定关键的歌曲定时功能，如音节，并可能注意到，开始和偏移。感觉反馈扰动导致成年鸣禽鸣唱输出的长期变化。目前尚不清楚这种扰动如何影响HVc的歌曲运动前神经模式。目的2将比较切断气管鞘（ts）神经之前和之后HVc的神经活动模式，这是一种改变听觉和本体感受反馈的操作。我们将使用多单元记录来初步表征这种扰动对HVc群体响应的影响。然后，我们将使用单单位记录来识别受感觉反馈操纵影响的神经元细胞类型。 最后，AIM 3将研究如何扰动HVc网络活动，无论是微损伤或刺激，影响正常刻板的歌曲输出的成年斑胸草雀。为了消除在完整的对侧HVc的代偿活动的可能性，空间限制的操作将在鸟类被迫唱歌只有一个歌曲系统的半球。所提出的研究直接解决了HVc中歌曲特征编码的空间和时间组织。