Functional Organization of the Song Motor Control System

Song电机控制系统的功能结构

• 批准号: 7174632
• 负责人: MARC F SCHMIDT
• 金额: $ 25.81万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-03-15 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7174632
• 关键词: Acoustics; Address; Adult; Affect; Auditory; Behavior; Behavior Control; Birds; Brain; Cell Nucleus; Complex; Condition; Contralateral; Corpus Callosum; Exhibits; Feedback; Learning; Left; Lesion; Midbrain structure; Modality; Motor; Motor Activity; Motor Pathways; Nature; Nerve; Neurons; Numbers; Output; Pathway interactions; Pattern; Play; Population; Principal Investigator; Production; Relative (related person); Respiratory Muscles; Role; Sensory; Series; Shapes; Side; Signal Transduction; Songbirds; Specific qualifier value; Stereotyping; Stimulus; Stream; Structure; Study models; System; Techniques; Testing; Time; base; bird song; cell type; insight; male; motor control; motor learning; programs; relating to nervous system; research study; response; sensory feedback; zebra finch

DESCRIPTION (provided by applicant): Birdsong is a hierarchically patterned learned motor behavior controlled by a nearly serially connected stream of nuclei. This pathway is bilaterally organized, with anatomically indistinguishable structures in each hemisphere. Little is known regarding the nature, or organization, of song features that are encoded by these structures. In the present proposal, we use a number of complimentary experimental techniques (single- and multi-unit recording, stimulation and lesions) to investigate the organization of song feature encoding in HVc, a key telencephalic song control nucleus. These studies will be performed in singing adult zebra finches (Taeniopygia guttata) under normal and perturbed sensory feedback conditions. In AIM 1, we exploit interhemispheric coordination of song motor activity in HVc to study the relationship between premotor activity and song output. We hypothesize that analysis of neural patterns recorded simultaneously in both hemispheres will provide insight into the hierarchical encoding of song features. We propose that patterns of coincident activity across hemispheres will specify key song timing features such as syllable, and possibly note, onset and offset. Sensory feedback perturbations cause long-term changes in song output of adult songbirds. It is not known how such perturbations affect song premotor neural patterns in HVc. AIM 2 will compare neural activity patterns in HVc before and directly after cutting the tracheosyringeal (ts) nerve, a manipulation that alters both acoustic and proprioceptive feedback. We will use multiunit recording to initially characterize the effect of such perturbations on the HVc population response. We will then use single-unit recordings to identify neuronal cell types that are affected by sensory feedback manipulation. Finally, AIM 3 will investigate how perturbations of HVc network activity, either by microlesions or stimulation, affect the normally stereotyped song output of adult zebra finches. To eliminate the possibility of compensatory activity in the intact contralateral HVc, spatially restricted manipulations will be performed in birds forced to sing with only one song system hemisphere. The proposed studies directly address the spatial and temporal organization of song feature encoding in HVc.

描述（由申请人提供）：鸟鸣是一种等级模式的习得运动行为，由几乎连续连接的核流控制。这条通路是双侧组织的，在每个半球具有解剖学上难以区分的结构。关于由这些结构编码的歌曲特征的性质或组织，人们知之甚少。在本提案中，我们使用了一些互补的实验技术（单单元和多单元记录，刺激和损伤）来研究HVc中歌曲特征编码的组织，HVc是一个关键的端脑歌曲控制核。这些研究将在正常和干扰的感觉反馈条件下对成年斑马雀（Taeniopygia guttata）进行歌唱。