ROLE OF CHEMOKINES IN MUCOSAL IMMUNITY: ORAL, RESPIRATORY & UROGENITAL PATHOGENS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The first aim of this project will assess the mucosal and systemic immunity in mice defective in the production or recognition of chemokines following mucosal immunization with Th1- or Th2-inducing regimens. The second aim will determine the G protein(s) - dependent and -independent mechanisms that these chemokines use to enhance acquired immunity. The third aim will assess the role of CD28-B7 and CD40-CD40L interactions as well as B and T cell differentiation for antibody, T helper cytokine, and cytotoxic T cell responses that occur in chemokine-mediated adaptive immunity. The fourth aim will define the Th1- and Th2-type cytokine -dependent and -independent pathways that result when chemokines are administered with protein antigen through mucosal or systemic routes. The proposed studies will provide important and novel information regarding the cellular mechanisms that chemokines, RANTES, Lptn, IP-10, and IL-8 use to induce and regulate systemic and mucosal immunity.